Mutual Funds Holding NBIX

Thompson MidCap Fund

NYLI Fiera SMID Growth Fund Institutional Class

NYLI Fiera SMID Growth Fund Class C

Franklin Biotechnology Discovery Fund Class C

Franklin Biotechnology Discovery Fund Advisor Class

AMG Renaissance Large Cap Growth Fund Class N

FullerThaler Behavioral Small-Mid Core Equity Fund Class A

FullerThaler Behavioral Small-Mid Core Equity Fund Institutional Class

Calvert Small/Mid-Cap Fund Class I

Calvert Small/Mid-Cap Fund Class C

AMG GW&K Small/Mid Cap Fund Class N

Rydex Biotechnology Fund Class A

Rydex Biotechnology Fund Class H

Eaton Vance Worldwide Health Sciences Fund Cl C

Eaton Vance WorldWide Health Sciences Fund Class R

Nomura Healthcare Fund Class C

Nomura Healthcare Fund Institutional Class

JPMorgan Mid Cap Growth Fund Class I

JPMorgan Mid Cap Growth Fund Class R6

JPMorgan Mid Cap Growth Fund Class R2

JPMorgan Mid Cap Growth Fund Class C

Loomis Sayles Small/Mid Cap Growth Fund Institutional Class

Impax Small Cap Fund CLASS A

Impax Small Cap Fund INSTITUTIONAL CLASS

NAA Mid Growth Fund Class A

Brown Advisory Sustainable Small-Cap Core Fund Class Institutional

DWS Small Cap Growth Fund Class A

DWS Small Cap Growth Fund Class Institutional

DWS Small Cap Growth Fund Class R6

Horizon Multi-Factor Small/Mid Cap Fund Advisor Class

Horizon Multi-Factor Small/Mid Cap Fund Institutional Class

Allspring SMID Cap Growth Fund Administrator Class

Allspring SMID Cap Growth Fund Institutional Class

Nomura Smid Cap Core Fund Class I

Nomura Smid Cap Core Fund Class C

Nomura Smid Cap Core Fund Class R

AQR LSE Fusion Fund Class N

SGI Global Equity Fund Class I

Hood River New Opportunities Fund Institutional Class

JPMorgan Growth Advantage Fund Class C

JPMorgan Growth Advantage Fund Class R2

JPMorgan Growth Advantage Fund Class R5

JPMorgan Growth Advantage Fund Class R3

S&P MidCap 400 Pure Growth Fund Class H

S&P MidCap 400 Pure Growth Fund Class A

Biotechnology UltraSector ProFund

WesMark Large Company Fund

Columbia Acorn Trust Acorn Fund Class S

Columbia Acorn Trust Acorn Fund Institutional Class III

Carillon Scout Mid Cap Fund Class R-6

Allspring Diversified Capital Builder Fund Class A

Allspring Diversified Capital Builder Fund Institutional Class

Columbia Acorn Trust Acorn Fund Class C

Columbia Multi-Manager Growth Strategies Fund Institutional 3 Class

Carillon Eagle Mid Cap Growth Fund Class C

Carillon Eagle Mid Cap Growth Fund Class R-6

Columbia Variable Portfolio - Acorn Fund

AQR Large Cap Defensive Style Fund Class I

AQR Large Cap Defensive Style Fund Class R6

Virtus Silvant Mid-Cap Growth Fund Class A

Thrivent Small Cap Growth Fund Class S

Voya Index Plus MidCap Portfolio Class S

VALIC Company I Capital Appreciation Fund

Mercer US Small/Mid Cap Equity Fund Class I

DWS Health and Wellness Fund Class A

DWS Health and Wellness Fund Class Institutional

Columbia Integrated Large Cap Value Fund Class Institutional

AQR Long-Short Equity Fund Class I

Victory Mid-Cap Core Growth Fund Class A

Victory Mid-Cap Core Growth Fund Class C

AQR Equity Market Neutral Fund Class N

AQR Equity Market Neutral Fund Class R6

BlackRock Mid-Cap Value Fund Class C

BlackRock Mid-Cap Value Fund Class K

Hussman Strategic Allocation Fund

Vanguard Windsor Fund Admiral Shares

Brown Advisory Small Cap Growth Fund Adv Shares

American Beacon Man Large Cap Growth Fund Class A

American Beacon Man Large Cap Growth Fund Investor Class

American Beacon Man Large Cap Growth Fund Y Class

Rydex Health Care Fund Class H

Rydex Health Care Fund Investor Class

AQR MS Fusion Fund Class I

AQR MS Fusion Fund Class R6

Dodge & Cox Stock Fund

Hood River Small Cap Growth Fund Retirement Class

Hood River Small Cap Growth Fund Investor Class

Vanguard Small Cap Growth Index Fund admiral Class

MFS New Discovery Fund Class A

MFS New Discovery Fund Class R1

MFS New Discovery Fund Class R2

MFS New Discovery Fund Class R4

MFS New Discovery Fund Class I

Empower S&P Mid Cap 400 Index Fund Investor Class

Northern Funds Mid Cap Index Portfolio

BNY Mellon Midcap Index Fund, Inc Class I

Federated Hermes Mid-Cap Index Fund Institutional Class

John Hancock Variable Insurance Trust Mid Index Trust Series II

JPMorgan Mid Cap Equity Fund Class A

JPMorgan Mid Cap Equity Fund Class C

JPMorgan Mid Cap Equity Fund Class R5

Principal MidCap S&P 400 Index Fund Institutional Class

Principal MidCap S&P 400 Index Fund Class R6

Principal MidCap S&P 400 Index Fund R-5 Class

JPMorgan Mid Cap Equity Fund Class I

Voya Russell Mid Cap Growth Index Portfolio Initial

Voya Russell Mid Cap Growth Index Portfolio Class S

S&P MidCap Index Fund Investor Class

Columbia Mid Cap Index Fund Institutional II Class

Mid-Cap Growth ProFund Service Class

Columbia Mid Cap Index Fund Class A

Vanguard S&P Mid-Cap 400 Index Fund Institutional Class

Janus Henderson Global Life Sciences Fund Class A

Janus Henderson Global Life Sciences Fund Class I

Janus Henderson Global Life Sciences Fund Class S

SIMT Tax-Managed Managed Volatility Fund Class Y

Columbia Integrated Large Cap Growth Fund Class Institutional II

Columbia Integrated Large Cap Growth Fund Class Institutional Class III

Mid-Cap ProFund

AQR Style Premia Alternative Fund Class R6

Franklin Global Allocation Fund Advisor Class

Franklin Global Allocation Fund Class A

Franklin Global Allocation Fund Class R6

Nuveen Quant Small/Mid Cap Equity Fund Premier Class

Nuveen Quant Small/Mid Cap Equity Fund Class I

Nuveen Quant Small/Mid Cap Equity Fund Class R6

Vanguard Explorer Fund Investor Class

American Century Disciplined Value Fund C Class

American Century Disciplined Value Fund R5 Class

American Century Disciplined Value Fund A Class

Yorktown Growth Fund Institutional Share Class

American Century Disciplined Value Fund Investor Class

Hartford Capital Appreciation HLS Fund Class IA

SGI US Large Cap Equity Fund Class A

Pace Small/Med Company Growth Equity Investments Fund Class A

SGI US Large Cap Equity Fund Class I

John Hancock Variable Insurance Trust Health Sciences Trust Series II

John Hancock Variable Insurance Trust Health Sciences Trust Series I

Mid-Cap 1.5x Strategy Fund Class C

JPMorgan Research Market Neutral Fund Class A

JPMorgan Research Market Neutral Fund Class I

AQR Alternative Risk Premia Fund Class I

T Rowe Price Mid-Cap Index Fund

T Rowe Price Mid-Cap Index Fund Class Z

ProFunds UltraMid-Cap ProFund Service Class

American Century Disciplined Core Equity Fund R5 Class

American Century Disciplined Core Equity Fund I Class

American Century Disciplined Core Equity Fund Investor Class

Dodge & Cox Balanced Fund Class X

JPMorgan US GARP Equity Fund Class R5

JPMorgan US GARP Equity Fund Class A

JPMorgan US GARP Equity Fund Class I

T. Rowe Price Health Sciences Portfolio

T. Rowe Price Health Sciences Fund Class I

BlackRock Advantage SMID Cap V.I. Fund Class I

American Century Disciplined Growth Fund I Class

American Century Disciplined Growth Fund Y Class

American Century Disciplined Growth Fund R Class

Voya Index Plus LargeCap Portfolio Initial

Voya Index Plus LargeCap Portfolio Advisor Class

Virtus Small-Cap Fund Institutional Class

Virtus Small-Cap Fund Class A

MFS Blended Research Small Cap Equity Fund Class C

MFS Blended Research Small Cap Equity Fund Class B

MFS Blended Research Small Cap Equity Fund Class R2

MFS Blended Research Small Cap Equity Fund Class R4

AQR Managed Futures Strategy HV Fund Class I

AQR Managed Futures Strategy HV Fund Class R6

BlackRock Advantage Large Cap Value Fund Class C

BlackRock Advantage Large Cap Value Fund Class K

Vanguard Capital Opportunity Fund

Vanguard Health Care Index Fund admiral class

Praxis Small Cap Index Fund Class I

Victory Extended Market Index Fund Class Fund shares

Vanguard Extended Market Index Fund Institutional Plus Class

Vanguard Extended Market Index Fund Investor Class

BlackRock Sustainable Aware Advantage Large Cap Core Fund Class C

BlackRock Sustainable Aware Advantage Large Cap Core Fund Institutional Class

BlackRock Advantage SMID Cap Fund Inc Institutional Class

BlackRock Advantage SMID Cap Fund Inc Class A

BlackRock Advantage SMID Cap Fund Inc Class R