First Trust Indxx Medical Devices ETF (MDEV) is a ETF from First Trust Portfolios (US) and Vanguard Total International Stock ETF (VXUS) is a ETF from Vanguard (US). Over the past year MDEV returned +5.47% while VXUS returned +27.82%. Year to date, MDEV is down 0.36% versus a gain of 14.57% for VXUS.

Over three years, MDEV compounded at +1.52% per year against +19.27% for VXUS; over five years the annualized figures are -4.69% and +9.28% respectively. Across the full 5-year window we track, VXUS has the edge at +4.86% annualized vs -3.61%. Past performance does not guarantee future results.

MDEV has been the more volatile fund, with annualized monthly volatility of 19.3% compared with 15.1% for VXUS. Lower volatility generally means a smoother ride, though it often comes with lower long-run returns.

The deepest peak-to-trough decline in our data was -42.3% for MDEV and -39.9% for VXUS. Drawdown depth is worth weighing if you expect to sell during market stress rather than ride it out.

The two funds' monthly returns correlate at 0.77. They usually move together, but the gap leaves some room for diversification.

MDEV charges 0.70% per year while VXUS charges 0.05%. On a $10,000 position that is $70 vs $5 annually, a gap of $65 per year that compounds over a long holding period. On income, MDEV currently yields 0.00% against 2.60% for VXUS.