ETFs Holding CYTK

Vanguard Explorer Fund Admiral Shares

Fidelity OTC K6 Portfolio Class K6

T Rowe Price Small-Cap Index Fund Institutional Class

T Rowe Price Small-Cap Index Fund Class Z

Vanguard Small Cap Growth Index Fund admiral Class

BlackRock Small Cap Index V.I. Fund Class I

SEI Select Small Cap ETF

Emerald Growth Fund Institutional Class

Fidelity OTC Portfolio

Fidelity OTC Portfolio Class A

Fidelity OTC Portfolio Class I

Emerald Growth Fund Class C

Voya VACS Index Series SC Portfolio

Virtus Income & Growth Fund Class C

Virtus Income & Growth Fund Institutional Class

Fidelity Advisor Mid Cap II Fund Class C

Fidelity Advisor Mid Cap II Fund Class M

Voya Russell Small Cap Index Portfolio Initial

Voya Russell Small Cap Index Portfolio Advisor Class

John Hancock Variable Insurance Trust Mid Index Trust Series II

John Hancock Variable Insurance Trust Mid Cap Index Trust Series I

JPMorgan US Small Company Fund Class I

JPMorgan US Small Company Fund Class A

JPMorgan US Small Company Fund Class R3

JPMorgan US Small Company Fund Class R5

Empower S&P Mid Cap 400 Index Fund Class L

Empower S&P Mid Cap 400 Index Fund Institutional Class

Columbia Research Enhanced Small Cap ETF

ProShares Ultra MidCap400

Fidelity Small Cap Index Fund

Nationwide Small Cap Index Fund Class A

Nationwide Small Cap Index Fund Institutional Service Class

Principal SmallCap Growth Fund Institutional Class

Principal SmallCap Growth Fund I Class R-5

T. Rowe Price Capital Appreciation and Income Fund Class I

Pacer WealthShield ETF

VALIC Company I Small Cap Index Fund

Vanguard Russell 2000 Index Fund Institutional

Federated Hermes MDT Small Cap Value Fund Class C

Federated Hermes MDT Small Cap Value Fund Class R

BlackRock Health Sciences Trust

First Trust Multi Cap Growth AlphaDEX Fund

State Street SPDR Portfolio S&P 400 Mid Cap ETF

BlackRock Advantage Small Cap Core Fund Investor C Class

BlackRock Advantage Small Cap Core Fund Class K

Fidelity Series Small Cap Discovery Fund

Principal MidCap S&P 400 Index Fund Institutional Class

Principal MidCap S&P 400 Index Fund Class R6

Principal MidCap S&P 400 Index Fund R-5 Class

Vanguard S&P Mid-Cap 400 Growth Index Fund Institutional Class

JPMorgan BetaBuilders US Mid Cap Equity ETF

Columbia Mid Cap Index Fund Institutional II Class

Columbia Mid Cap Index Fund Institutional Class

Russell US Small Cap Equity Fund

VALIC Company I Mid Cap Index Fund

Inspire Small/Mid Cap ETF

State Street SPDR S&P 400 Mid Cap Value ETF

iShares ESG Aware MSCI USA Small-Cap ETF

Federated Hermes Mid-Cap Index Fund Institutional Class

BlackRock Health Sciences Term Trust

John Hancock Variable Insurance Trust Small Cap Index Trust Series Nav

John Hancock Variable Insurance Trust Small Cap Index Trust Series I

Mid-Cap ProFund

Mid-Cap Value ProFund

Russell US Small Cap Equity Fund Class Y

Russell US Small Cap Equity Fund Class C

Royce Small Cap Fund Institutional Class

Russell US Small Cap Equity Fund Class M

Royce Small Cap Fund Service Class

Allspring Disciplined Small Cap Fund Class A

Allspring Disciplined Small Cap Fund Institutional Class

Fidelity Flex Mid Cap Index Fund

Mid-Cap 1.5x Strategy Fund Class C

Mid-Cap 1.5x Strategy Fund Class H

Russell 2000 1.5x Strategy Fund Class H

BlackRock Health Sciences Opportunity Investor A Class

BlackRock Health Sciences Opportunities Portfolio Institutional Class

ProFunds Ultra Small-Cap ProFund Service Class

BlackRock Health Sciences Opportunities Portfolio Class K

iShares Morningstar Small-Cap ETF

Fidelity Growth Discovery Fund Class K

Federated Hermes MDT Market Neutral Fund Class IS

Wilshire Small Company Value Fund Investment Class

Columbia Multi-Manager Small Cap Equity Strategies Fund Intitutional Class

Nomura Healthcare Fund Class A

Nomura Healthcare Fund Class R

Fidelity Advisor Equity Growth Fund Class C

Fidelity Advisor Equity Growth Fund Class M

Fidelity Advisor Series Equity Growth Fund

ProFunds UltraMid-Cap ProFund Investor Class

Russell 2000 Fund Class H

Russell 2000 Fund Class C

T. Rowe Price Integrated US Small-Mid Cap Core Equity Fund Class I

Fidelity Fundamental Large Cap Growth ETF

VY JPMorgan Small Cap Core Equity Portfolio Service

VY JPMorgan Small Cap Core Equity Portfolio Initial

Praxis Small Cap Index Fund Class I

The Gabelli Healthcare & Wellness RX Trust

Fidelity MSCI Health Care Index ETF

Avantis Inflation Focused Equity ETF

Mid-Cap Growth ProFund Service Class

T. Rowe Price Integrated US Small-Cap Growth Equity Fund Investor Class

T. Rowe Price New Horizons Fund Investor Class

T. Rowe Price Integrated US Small-Cap Growth Equity Fund Advisor class

Vanguard Health Care Index Fund admiral class

ProShares UltraPro Russell2000

Fidelity ZERO Extended Market Index Fund

Small-Cap ProFund

Victory Extended Market Index Fund Class Fund shares

Vanguard Small Cap Index Fund Institutional Plus

Virtus Diversified Income & Convertible Fund

Virtus Convertible & Income Fund II

BlackRock Advantage SMID Cap Fund Inc Class C

BlackRock Advantage SMID Cap Fund Inc Class K

BlackRock Advantage SMID Cap V.I. Fund Class III

Invesco RAFI US 1500 Small-Mid ETF

Neuberger Berman Core Equity ETF

AQR Small Cap Momentum Style Fund Class I

Fidelity Advisor Diversified Stock Fund Class C

Fidelity Advisor Diversified Stock Fund Class I

Fidelity Extended Market Index Fund

AQR Small Cap Momentum Style Fund Class R6

Vanguard Extended Market Index Fund Institutional Plus Class

Vanguard Extended Market Index Fund Investor Class

iShares Russell Small/Mid-Cap Index Fund Class Investor A

iShares Russell Small/Mid-Cap Index Fund Institutional Class

SMALLCAP World Fund Class 529-C

SMALLCAP World Fund Class 529-A

SMALLCAP World Fund Class 529-F-3

Nationwide Bailard Small Cap Value Fund Class A

Nationwide Bailard Small Cap Value Fund Class M

SMALLCAP World Fund Class R6

SMALLCAP World Fund Inc Class R-1 Shares

SMALLCAP World Fund Inc Class R-2 Shares

SMALLCAP World Fund Inc Class R-4 Shares

Russell Tax-Managed US Mid & Small Cap Fund Class M

Russell Tax-Managed US Mid & Small Cap Fund Class C

SMALLCAP World Fund Class F1

SMALLCAP World Fund Class F3

SMALLCAP World Fund Class A

T. Rowe Price Spectrum Moderate Growth Allocation Fund Class I

John Hancock Multifactor Mid Cap ETF

Fidelity Puritan K6 Fund Class K6

Russell 2000 2x Strategy Fund Class C

T. Rowe Price Spectrum Moderate Allocation Fund Class I

Virtus Equity & Convertible Income Fund

Federated Hermes MDT Small Cap Core ETF

Fidelity Small Cap Growth Index Fund

Fidelity Puritan Fund

Impax Sustainable Allocation Fund Institutional Class

Wilshire Small Company Growth Portfolio Fund Investor Class

Column Small Cap Fund

Vanguard Russell 2000 Growth ETF

Goldman Sachs Small Cap Value Insights Fund Cl A

Goldman Sachs Small Cap Value Insights Fund Institutional Class

Goldman Sachs Small Cap Value Insights Fund Class R6

Goldman Sachs Small Cap Value Insights Fund Cl R

Fidelity Advisor New Insights Fund Class I

Fidelity Advisor New Insights Fund Class A

Fidelity Series Sustainable US Market Fund

Fidelity Advisor New Insights Fund Class Z

T. Rowe Price Spectrum Conservative Allocation Fund Investor Class

Humankind US Stock ETF

Bridge Builder Small/Mid Cap Value Fund

John Hancock Variable Insurance Trust Strategic Equity Allocation Trust Series Nav

iShares Core S&P US Growth ETF

Fidelity Nasdaq Composite Index ETF

iShares Core S&P Total US Stock Market ETF

Strive 1000 Growth ETF

Destinations Small-Mid Cap Equity Fund Class I

Meeder Quantex Fund Retail Class

Strategic Advisers US Total Stock Fund

Principal SmallCap Value Fund II Class R-3

Principal SmallCap Value Fund Institutional Class

Principal SmallCap Value Fund II Class R6

Meeder Quantex Fund Institutional Class

State Street Total Return V.I.S. Fund CL1

Vanguard Growth and Income Fund Admiral Shares

Vanguard Growth and Income Fund Investor Shares

Vanguard Total Stock Market Index Fund Institutional Select Shares

Vanguard Total Stock Market Index Fund Investor Class

MFS Global Alternative Strategy Fund Class A

MFS Global Alternative Strategy Fund Class C

MFS Global Alternative Strategy Fund Class B

MFS Global Alternative Strategy Fund Class R5

Goldman Sachs MarketBeta US 1000 Equity ETF