Nuvalent, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for patients with cancer. Its lead product candidates are NVL-520, a novel ROS1-selective inhibitor to address the clinical challenges of emergent treatment resistance, central nervous system (CNS)-related adverse events, and brain metastases that may limit the use of ROS1 tyrosine kinase inhibitors (TKIs) for patients with ROS proto-oncogene 1 (ROS1)-positive non-small cell lung cancer (NSCLC) which is under the Phase 2 portion of the ARROS-1 Phase 1/2 clinical trial; NVL-655, a brain-penetrant ALK-selective inhibitor, to address the clinical challenges of emergent treatment resistance, CNS-related adverse events, and brain metastases that might limit the use of first-, second-, and third-generation ALK inhibitors that is under the Phase 2 portion of the ALKOVE-1 clinical trial; and NVL-330, a brain-penetrant human epidermal growth factor receptor 2 (HER2)-selective inhibitor designed to treat tumors driven by HER2ex20, brain metastases, and avoiding treatment-limiting adverse events including due to off-target inhibition of wild-type EGFR that is in Phase 1a/1b clinical trial. The company was incorporated in 2017 and is headquartered in Cambridge, Massachusetts.

Nuvalent Inc.

Wedbush analyst maintained a Buy rating on Nuvalent today and set a price target of $125.00. Currently, the analyst consensus on Nuvalent is a Stro...

Wedbush Sticks to Its Buy Rating for Nuvalent (NUVL)

The latest announcement is out from Nuvalent ( ($NUVL) ). On November 17, 2025, Nuvalent announced positive topline pivotal data for neladalkib in ...

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1	Symbol	Price	Change	Volume
2	NUVL	$104.80	-1.05%	530.44K
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1	Symbol	Price	Change	Vol
2	NUVL	$104.80	-1.0%	530.44K
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