ETFs Holding VRTX

ClearBridge Growth Fund Class C

ClearBridge Growth Fund Class A

ClearBridge Variable Growth Portfolio Class I

Virtus KAR Health Sciences Fund Institutional Class

Virtus KAR Health Sciences Fund Class C

Franklin Biotechnology Discovery Fund Class A

Franklin Biotechnology Discovery Fund Class R6

ProShares Ultra Nasdaq Biotechnology

Rydex Biotechnology Fund Class A

Rydex Biotechnology Fund Class H

Global X Genomics & Biotechnology ETF

PGIM Jennison Health Sciences Fund Class C

PGIM Jennison Health Sciences Fund Class R6

PGIM Jennison Health Sciences Fund Class R

Eaton Vance Worldwide Health Sciences Fund Cl C

Eaton Vance WorldWide Health Sciences Fund Class R

Saratoga Health & Biotechnology Portfolio Class I

Saratoga Health & Biotechnology Portfolio Class C

Loomis Sayles Growth Fund Class A

Loomis Sayles Growth Fund Class C

iShares Health Innovation Active ETF

Baron Health Care Fund Retail Class

Baron Health Care Fund Class R6

Tema Heart & Health ETF

Vitality Portfolio Class R6

Vitality Portfolio Class C

Edgewood Growth Fund Institutional Class

DWS Health and Wellness Fund Class A

DWS Health and Wellness Fund Class Institutional

Victory Pioneer Fundamental Growth Fund Class C

Domini Sustainable Solutions Fund Institutional Class

Victory Pioneer Fundamental Growth Fund Class R

KraneShares Wahed Alternative Income Index ETF

Hartford Healthcare HLS Fund Class IA

The Hartford Healthcare Fund Class A

The Hartford Healthcare Fund Class C

The Hartford Healthcare Fund Cl R4

The Hartford Healthcare Fund Cl R5

The Hartford Healthcare Fund Class Y

AMCAP Fund Class F-2

AMCAP Fund Class F-1

AMCAP Fund Class 529-C

AMCAP Fund Class 529-F-1

AMCAP Fund Class 529-F-3

AMCAP Fund Class R-5E

AMCAP Fund Class R-1

AMCAP Fund Class R-2

AMCAP Fund Class R-4

Formidable Fortress ETF

Manning & Napier ProBlend Maximum Term Series Class S

Manning & Napier ProBlend Maximum Term Series Class W

Manning & Napier ProBlend Maximum Term Series Class L

Putnam Global Health Care Fund Class R6

Putnam Global Health Care Fund Class A

Putnam Global Health Care Fund Class Y

Fidelity Healthy Future Fund

Loomis Sayles Global Growth Fund Class C

Loomis Sayles Global Growth Fund Class N

William Blair Global Leaders Fund Class I

iShares US Healthcare ETF

Clearbridge Large Cap Growth Fund Class O

ClearBridge Large Cap Growth Fund Class IS

ClearBridge Large Cap Growth Fund Class I

Capital Group US Large Growth ETF

BlackRock Health Sciences Opportunity Service Class

BlackRock Health Sciences Opportunity Fund Investor C Class

BlackRock Health Sciences Opportunities Portfolio Class R Shares

VanEck Healthcare TruSector ETF

Janus Henderson Global Life Sciences Fund Class A

Janus Henderson Global Life Sciences Fund Class I

Janus Henderson Global Life Sciences Fund Class S

Allspring Special Large Value ETF

Invesco Health Care Fund Class A

Invesco Health Care Fund Class R

Vanguard Health Care Fund Admiral Shares

Invesco Health Care Fund Class R6

ROBO Global Healthcare Technology and Innovation ETF

GreenFi Redwood Fund

Fidelity MSCI Health Care Index ETF

Invesco S&P 500 Equal Weight Health Care ETF

Health Care UltraSector ProFund Investor

Manning & Napier ProBlend Extended Term Series Class S

Manning & Napier ProBlend Extended Term Series Class W

Manning & Napier ProBlend Extended Term Series Class L

Vanguard Baillie Gifford Global Positive Impact Stock Fund Class Investor Shares

Vanguard Health Care ETF

Davidson Multi-Cap Equity Fund Class I

John Hancock Variable Insurance Trust Health Sciences Trust Series Nav

iShares Global Healthcare ETF

The Investment Company of America Class C

The Investment Company of America Class A

The Investment Company of America Class 529-C

The Investment Company of America Class 529-F1

The Investment Company of America Class 529-F-2

The Investment Company of America Class F2

The Investment Company of America Class R-1 Shares

The Investment Company of America Class R-3 Shares

The Investment Company of America Class R-4 Shares

The Investment Company of America - Class R-5E

Nomura Healthcare Fund Class A

Nomura Healthcare Fund Class R

T. Rowe Price Health Sciences Portfolio

Schwab Health Care Fund

Goldman Sachs MSCI World Private Equity Return Tracker ETF

The Growth Fund of America Class 529-C

The Growth Fund of America Class 529-E

The Growth Fund of America Class 529-F-2

The Growth Fund of America Class F-3

The Growth Fund of America Class F-1

The Growth Fund of America Class R-2

The Growth Fund of America Class R-3

The Growth Fund of America Class R-5

The Growth Fund of America Class R-6

ProShares Ultra Health Care

ClearBridge Variable Large Cap Growth Portfolio Class I

Lord Abbett Health Care Fund

Lord Abbett Health Care Fund Class I

Lord Abbett Health Care Fund Class F

Lord Abbett Health Care Fund Class R6

Value Line Larger Companies Focused Fund Investor Class

Columbia Multi-Manager Growth Strategies Fund Institutional 3 Class

iShares ESG Optimized MSCI USA Min Vol Factor ETF

Columbia Large Cap Growth ETF

Trillium ESG Global Equity Fund Investor Class

American Funds The New Economy Fund Class A

American Funds The New Economy Fund Class C

American Funds The New Economy Fund other Class

American Funds The New Economy Fund Class 529-F-2

American Funds The New Economy Fund Class 529-F-3

American Funds The New Economy Fund Class R1 Shares

American Funds The New Economy Fund Class R2 Shares

American Funds The New Economy Fund Class R5 Shares

American Funds The New Economy Fund Class R6

Direxion Daily Healthcare Bull 3X ETF

Nuveen Winslow Large-Cap Growth ESG Fund Class C

Nuveen Winslow Large-Cap Growth ESG Fund Class R6

Victory Pioneer Fund Class A

Victory Pioneer Fund Class R

Columbia Intrinsic Value Fund Class C

Columbia Intrinsic Value Fund Class I

Columbia Intrinsic Value Fund Class I2

NYLI Winslow Large Cap Growth Fund Class A

NYLI Winslow Large Cap Growth Fund Class C

NYLI Winslow Large Cap Growth Fund Investor Class

NYLI Winslow Large Cap Growth Fund Simple Class

NYLI Winslow Large Cap Growth Fund Class R2

One Global ETF

BNY Mellon Sustainable US Equity Fund, Inc. Class I

BNY Mellon Sustainable US Equity Fund, Inc. Class A

BNY Mellon Sustainable US Equity Fund, Inc. Class Y

Columbia Integrated Large Cap Growth Fund Class A

Cantor Fitzgerald Large Cap Focused Fund Institutional Class

Cantor Fitzgerald Large Cap Focused Fund Class R6

Columbia Integrated Large Cap Value Fund Class Institutional

Sparrow Growth Fund Class A

Acruence Active Hedge US Equity ETF

Reynders McVeigh Core Equity Fund

Rydex Health Care Fund Class A

Rydex Health Care Fund Class C

Boston Common ESG Impact US Equity Fund

Columbia Contrarian Core Fund Class I2

Columbia Contrarian Core Fund class C

Columbia Contrarian Core Fund Class S

Allspring Large Cap Value Fund Class A

Allspring Large Cap Value Fund Institutional Class

Victory Growth Fund Institutional Class

Wisdomtree BioRevolution Fund

MassMutual Blue Chip Growth Fund Administrative class

MassMutual Blue Chip Growth Fund Class R5

MassMutual Blue Chip Growth Fund Service Class

MassMutual Blue Chip Growth Fund Class Y

SEI QiM US Large Cap Quality Active ETF

Empower Large Cap Growth Fund Investor Class

Goldman Sachs Large Cap Growth Insights Fund Class C Shares

Goldman Sachs Large Cap Growth Insights Fund Investor Class

Goldman Sachs Large Cap Growth Insights Fund Class R

Goldman Sachs Large Cap Growth Insights Fund Service Shares

JPMorgan Equity Premium Income Fund Class A

JPMorgan Equity Premium Income Fund Class R5

JPMorgan Equity Premium Income ETF

Victory Pioneer Balanced Fund Class Y