FMED vs VTI
Fidelity Disruptive Medicine ETF vs Vanguard Morningstar Total Stock Market ETF
Which is better, FMED or VTI?
Each has led over a different period.
VTI has a lower expense ratio. FMED led over 1Y, VTI over 3Y and the full window. VTI is less concentrated, with 33.3% of the fund in its ten largest positions against 34.1%.
MarketXLS is not an investment adviser. This comparison is generated automatically from market data and is for information only. A Best mark means the better reading on that one measure, not a recommendation to buy.
Side-by-Side Comparison
| Metric | FMED | VTI |
|---|---|---|
| Expense Ratio | 0.50% | 0.03%Best |
| AUM | $52M | $690.1B |
| Dividend Yield | 0.00% | 1.03% |
| Holdings | 144 | 3,524 |
| YTD Return | +18.34%Best | +13.35% |
| 1Y Return | +25.49%Best | +15.92% |
| 3Y Return (annualized) | +14.19% | +23.41%Best |
| 5Y Return (annualized) | - | +12.83% |
| Volatility (annualized) | 19.2% | 12.9%Best |
| Max Drawdown | -21.8% | -19.3%Best |
| $10,000 over 3.3 years | $12,695 | $18,307Best |
| Top 10 Weight | 34.1% | 33.3%Best |
| Fund Family | Fidelity Investments (US) | Vanguard (US) |
| Category | Equity | Equity |
| Style | Large Cap Blend | Large Cap Blend |
| Inception | Feb 13, 2023 | May 24, 2001 |
Volatility and max drawdown, and the $10,000 over 3.3 years row, are measured over the window both funds cover: Jun 12, 2023 to Oct 2, 2026 (3.3 years).
FMED vs VTI growth
Month-end closes. Both lines start at 0% in the first month shown, so the gap between them is the difference in growth across that window. The full view covers the 3.3 years both funds cover.
FMED vs VTI Performance
Fidelity Disruptive Medicine ETF (FMED) is an ETF from Fidelity Investments (US) and Vanguard Morningstar Total Stock Market ETF (VTI) is an ETF from Vanguard (US). Over the past year FMED returned +25.49% while VTI returned +15.92%. Year to date, FMED is up 18.34% versus a gain of 13.35% for VTI.
Over three years, FMED compounded at +14.19% per year against +23.41% for VTI.
Past performance does not guarantee future results.
Risk: Volatility and Drawdowns
FMED has been the more volatile fund, with annualized monthly volatility of 19.2% compared with 12.9% for VTI. Lower volatility generally means a smoother ride, though it often comes with lower long-run returns.
The deepest peak-to-trough decline in our data was -21.8% for FMED and -19.3% for VTI. Drawdown depth is what each fund did in the worst stretch of the window measured above.
The two funds' monthly returns correlate at 0.53. They move together some of the time, and apart the rest.
Fees and Cost Over Time
FMED charges 0.50% per year while VTI charges 0.03%. On a $10,000 position that is $50 vs $3 annually, a gap of $47 per year that compounds over a long holding period. On income, FMED currently yields 0.00% against 1.03% for VTI.
Holdings Overlap
82.5% of FMED's money is in holdings VTI also owns. 3.3% of VTI's money is in holdings FMED also owns.
Most of FMED is already inside VTI. Owning both mostly buys the same companies twice.
The two holdings books were reported 46 days apart, FMED as of Sep 15, 2026 and VTI as of Jul 31, 2026, so some of the difference between them is the time between the two reports rather than the funds.
59 positions in common, counted across the 72 positions we hold weights for in FMED and 3,463 in VTI, against full books of 144 and 3,524.
What only one of them owns
Our book lists 1,115 positions for VTI that do not appear in our book for FMED (94.2% of the fund), and 6 for FMED that do not appear in VTI (6.2%).
Some of those will be the same company recorded under a different code in one of the two books, so the real difference in what you would own is no larger than this and may be smaller. We do not name the individual positions here for that reason.
Top Shared Holdings
| Stock | Weight in FMED | Weight in VTI | Difference |
|---|---|---|---|
| TXG10x Genomics Inc Com Usd 1 Cl A | 5.84% | 0.01% | 5.83% |
| TMOThermo Fisherscientific Inc. | 3.89% | 0.30% | 3.59% |
| DHRDanaher Corporation | 3.59% | 0.17% | 3.42% |
| NTRANatera Inc | 3.67% | 0.05% | 3.62% |
| LFSTLifestance Health Group Inc Ordinary Shares | 3.23% | 0.00% | 3.23% |
| RVMDRevolution Medicines Inc | 2.92% | 0.05% | 2.87% |
| ILMNIllumina, Inc. | 2.80% | 0.04% | 2.76% |
| ALNYAlnylam Pharmaceuticals Inc. | 2.48% | 0.04% | 2.44% |
| HTFLHeartflow, Inc. | 2.48% | 0.00% | 2.48% |
| COGTCogent Biosciences Inc | 2.26% | 0.01% | 2.25% |
82.5% of FMED is already inside VTI.
You probably hold more than these two. Add the rest and see how much of the whole book is the same companies twice.
Free for up to 10 holdings. No account needed.
Frequently Asked Questions
Which is cheaper, FMED or VTI?
FMED has an expense ratio of 0.50% while VTI charges 0.03%. VTI is the cheaper option, by $47 a year on a $10,000 investment.
Which performed better, FMED or VTI?
Over the past year FMED returned +25.49% vs +15.92% for VTI, so FMED leads on 1-year performance. Past performance does not guarantee future results. This is information, not a recommendation.
Which is riskier, FMED or VTI?
FMED has been the more volatile fund at 19.2% annualized versus 12.9% for VTI. Worst drawdown: FMED -21.8% vs VTI -19.3%.
Should I hold both FMED and VTI?
FMED and VTI have a monthly-return correlation of 0.53, so their returns are far enough apart for the mix to behave differently from either one alone. This is information, not a recommendation.
What is the holdings overlap between FMED and VTI?
82.5% of FMED's money is in holdings VTI also owns. 3.3% of VTI's is in holdings FMED also owns. They hold 59 positions in common, counted across the 72 positions we hold weights for in FMED and 3,463 in VTI.
Which pays a higher dividend, FMED or VTI?
FMED yields 0.00% while VTI yields 1.03%, so VTI currently pays the higher dividend yield.
Is VTI better than FMED?
VTI has a lower expense ratio. FMED led over 1Y, VTI over 3Y and the full window. VTI is less concentrated, with 33.3% of the fund in its ten largest positions against 34.1%. Which one suits a particular account depends on what it is for. This is information, not a recommendation.