Mutual Funds Holding CYTK

AMG GW&K Small Cap Value Fund Class I

Baron Health Care Fund Retail Class

Baron Health Care Fund Class R6

T. Rowe Price Small Cap Stock Fund, Inc Investor Class

T. Rowe Price Small Cap Stock Fund, Inc Advisor Class

Rydex Biotechnology Fund Class A

Rydex Biotechnology Fund Class H

Segall Bryant & Hamill Small Cap Growth Fund Institutional Class

Impax Small Cap Fund CLASS A

Impax Small Cap Fund INSTITUTIONAL CLASS

Thornburg Investment Trust Small/Mid Cap Growth Fd Cl R4

Thornburg Investment Trust Small/Mid Cap Growth Fd Cl R3

Thornburg Investment Trust Small/Mid Cap Growth Fd Cl I

Principal SmallCap Fund Class J

Principal SmallCap Fund Class R-5

Principal SmallCap Fund Class R6

Columbia Small Cap Value and Inflection Fund Class A

Columbia Small Cap Value and Inflection Fund Institutional Class III

Columbia Small Cap Value and Inflection Fund Class S

Biotechnology UltraSector ProFund

Fidelity Advisor Biotechnology Fund Class C

Fidelity Advisor Biotechnology Fund Class M

AlphaCentric Life Sciences and Healthcare Fund Class A

AlphaCentric Life Sciences and Healthcare Fund Class I

John Hancock Variable Insurance Trust Small Company Value Trust Series I

Brown Advisory Small Cap Growth Fund Inst Shares

Brown Advisory Small Cap Growth Fund Investor Class

AB Small Cap Value Portfolio

T. Rowe Price Small Cap Value Fund Advisor Class

T. Rowe Price Small Cap Value Fund, Inc Class I

Carillon Chartwell Small Cap Fund Class A

Carillon Chartwell Small Cap Fund Class R-6

William Blair Small Cap Growth Fund Class I

William Blair Small Cap Growth Fund Class N

Carillon Chartwell Small Cap Growth Fund Class C

Carillon Chartwell Small Cap Growth Fund Class R6

Vanguard Health Care Fund Admiral Shares

AMG GW&K Small Cap Core Fund Class N

AMG GW&K Small Cap Core Fund Class Z

Hartford Healthcare HLS Fund Class IA

Goldman Sachs Small Cap Value Fund Investor Class

Goldman Sachs Small Cap Value Fund A Shares

Goldman Sachs Small Cap Value Fund Class R6

Goldman Sachs Small Cap Value Fund Class P Shares

William Blair Small-Mid Cap Growth Fund Class R6

JPMorgan Small Cap Growth Fund Class R4

JPMorgan Small Cap Growth Fund Class R6

JPMorgan Small Cap Growth Fund Class L

JPMorgan Small Cap Growth Fund Class I

JPMorgan Small Cap Growth Fund Class A

Fidelity Advisor Health Care Fund Class M

Fidelity Advisor Health Care Fund Class I

Fidelity Select Health Care Portfolio

MFS New Discovery Fund Class C

MFS New Discovery Fund Class B

MFS New Discovery Fund Class R6

MFS New Discovery Fund Class R3

BNY Mellon Small/Mid Cap Growth Fund Class A

BNY Mellon Small/Mid Cap Growth Fund Class Y

Fidelity Select Biotechnology Portfolio

Federated Hermes Kaufmann Small Cap Fund Class R6

Federated Hermes Kaufmann Small Cap Fund Class A

Federated Hermes Kaufmann Small Cap Fund Class R

Goldman Sachs Small/Mid-Cap Growth Fund Service Class

Goldman Sachs Small/Mid-Cap Growth Fund Inst Cl

Goldman Sachs Small/Mid-Cap Growth Fund Class R

Goldman Sachs Small/Mid-Cap Growth Fund Investor Class

The Hartford Healthcare Fund Class A

The Hartford Healthcare Fund Class C

The Hartford Healthcare Fund Cl R4

The Hartford Healthcare Fund Cl R5

The Hartford Healthcare Fund Class Y

John Hancock Variable Insurance Trust Capital Appreciation Value Trust Series Nav

Fidelity Advisor Stock Selector Small Cap Fund Class A

Fidelity Advisor Stock Selector Small Cap Fund Class I

Franklin Small Cap Growth Fund Class C

Franklin Small Cap Growth Fund Class R6

Franklin Small Cap Growth Fund Class R

Federated Hermes Kaufmann Fund Class A

Federated Hermes Kaufmann Fund Class C

Fidelity Series Small Cap Opportunities Fund

Hartford Small Company HLS Fund Class IA

John Hancock Variable Insurance Trust Small Stock Trust Series Nav

Empower T. Rowe Price Mid Cap Growth Fund Invoice Class

T. Rowe Price Capital Appreciation Fund Advisor Class

T. Rowe Price Mid-Cap Growth Portfolio Class II

T. Rowe Price Capital Appreciation Fund Class I

Empower Small Cap Growth Fund Investor Class

John Hancock Variable Insurance Trust Health Sciences Trust Series Nav

T. Rowe Price Mid-Cap Growth Fund Advisor Class

T. Rowe Price Mid-Cap Growth Fund Investor Class

T. Rowe Price Mid-Cap Growth Fund-R Class

Fidelity Small Cap Value Index Fund

Goldman Sachs Small/Mid Cap Value Fund Class A

Goldman Sachs Small/Mid Cap Value Fund Class C

Goldman Sachs Small/Mid Cap Value Fund Institutional Class

John Hancock Funds II Capital Appreciation Value Fund Class NAV

VALIC Company I Small Cap Growth Fund

MFS Blended Research Small Cap Equity Fund Class C

MFS Blended Research Small Cap Equity Fund Class B

MFS Blended Research Small Cap Equity Fund Class R2

MFS Blended Research Small Cap Equity Fund Class R4

T. Rowe Price Health Sciences Portfolio

Calamos Timpani Small Cap Growth Fund Class A

Calamos Timpani Small Cap Growth Fund Class R6

Fidelity Advisor Small Cap Growth Fund Class C

Fidelity Advisor Small Cap Growth Fund

Fidelity Advisor Small Cap Growth Fund Class Z

Fidelity Advisor Small Cap Fund Class A

Fidelity Advisor Small Cap Fund Class I

Fidelity Advisor Small Cap Fund Class Z

The Hartford Small Company Fund Class C

The Hartford Small Company Fund Class F

The Hartford Small Company Fund Class R3

The Hartford Small Company Fund Class R5

Calamos Timpani Small Cap Growth Fund Class C

Hartford Small Cap Growth HLS Fund Class IA

JPMorgan Small Cap Value Fund Class R5

JPMorgan Small Cap Value Fund Class R6

JPMorgan Small Cap Value Fund Class C

JPMorgan Small Cap Value Fund Class A

T. Rowe Price Health Sciences Fund Class I

American Century Small Cap Growth Fund Class A

American Century Small Cap Growth Fund R6 Cl

American Century Small Cap Growth Fund R5 Class

American Century Small Cap Growth Fund I Class

American Century Small Cap Growth Fund Y Class

The Hartford Small Cap Growth Fund Class C

The Hartford Small Cap Growth Fund Class R3

The Hartford Small Cap Growth Fund Class R4

The Hartford Small Cap Growth Fund Class R5

Goldman Sachs Small Cap Growth Fund Class P

Goldman Sachs Small Cap Growth Fund Class C

Goldman Sachs Small Cap Growth Fund Class A

Rydex Health Care Fund Class H

Rydex Health Care Fund Investor Class

Voya Small Cap Growth Fund Class I

VALIC Company I Small Cap Value Fund

Voya Small Cap Growth Fund Class C

Voya Small Cap Growth Fund Class W

MassMutual Small Cap Growth Equity Fund Class Y

MassMutual Small Cap Growth Equity Fund Class R4

MassMutual Small Cap Growth Equity Fund Class R3

MassMutual Small Cap Growth Equity Fund Class I

MassMutual Mid Cap Growth Fund Class R4

MassMutual Mid Cap Growth Fund Service Class

MassMutual Mid Cap Growth Fund Class R5

MassMutual Mid Cap Growth Fund Class Y

Columbia Integrated Small Cap Growth Fund Class Institutional

Fidelity Flex Mid Cap Focused Index Fund

Invesco Small Cap Growth Fund Class C

Invesco Small Cap Growth Fund Investor Class

Invesco Small Cap Growth Fund Class R5

Franklin Biotechnology Discovery Fund Class A

Franklin Biotechnology Discovery Fund Class R6

VY T. Rowe Price Capital Appreciation Portfolio Service

VY T. Rowe Price Capital Appreciation Portfolio Initial

VY T. Rowe Price Capital Appreciation Portfolio Class R6

JPMorgan Small Cap Blend Fund Class R6

Nuveen Small Cap Blend Index Fund Retirement Class

JPMorgan Small Cap Blend Fund Class C

Thrivent Small Cap Index Portfolio

NYLI WMC Small Companies Fund Class A

NYLI WMC Small Companies Fund Class C

Fidelity Advisor Stock Selector Mid Cap Fund Class I

Fidelity Advisor Stock Selector Mid Cap Fund Class C

Fidelity Advisor Stock Selector Mid Cap Fund

BNY Mellon Small Cap Multi-Strategy Fund Class M Shares

Optimum Small-Mid Cap Growth Fund Class C

PGIM Quant Solutions Small-Cap Value Fund Class R2

PGIM Quant Solutions Small-Cap Value Fund Class Z

PGIM Quant Solutions Small-Cap Value Fund Class A

PGIM Quant Solutions Small-Cap Value Fund Class R6

Invesco Health Care Fund Class A

Invesco Health Care Fund Class R

Vanguard Explorer Fund Investor Class

Invesco Health Care Fund Class R6

Northern Small Cap Index Fund

T Rowe Price Small-Cap Index Fund

Vanguard Small Cap Growth Index Fund Investor Class