IBRN vs VOO
iShares Neuroscience and Healthcare ETF vs Vanguard S&P 500 ETF
Quick Verdict
VOO has a lower expense ratio. IBRN delivered stronger 1-year returns. VOO offers more diversification with 505 holdings.
Side-by-Side Comparison
| Metric | IBRN | VOO | Winner |
|---|---|---|---|
| Expense Ratio | 0.47% | 0.03% | |
| AUM | $6M | $979.0B | |
| Dividend Yield | 0.82% | 1.09% | |
| Holdings | 80 | 509 | |
| YTD Return | +23.25% | +13.79% | |
| 1Y Return | +70.47% | +23.01% | |
| 3Y Return (annualized) | +18.89% | +21.78% | |
| 5Y Return (annualized) | - | +13.39% | |
| Volatility (annualized) | 21.4% | 14.1% | |
| Max Drawdown | -35.4% | -34.3% | |
| Fund Family | iShares by BlackRock (US) | Vanguard (US) | |
| Category | Equity | Equity | |
| Inception | Aug 24, 2022 | Sep 7, 2010 |
IBRN vs VOO Performance
iShares Neuroscience and Healthcare ETF (IBRN) is a ETF from iShares by BlackRock (US) and Vanguard S&P 500 ETF (VOO) is a ETF from Vanguard (US). Over the past year IBRN returned +70.47% while VOO returned +23.01%. Year to date, IBRN is up 23.25% versus a gain of 13.79% for VOO.
Over three years, IBRN compounded at +18.89% per year against +21.78% for VOO. Across the full 4-year window we track, VOO has the edge at +13.57% annualized vs +12.93%. Past performance does not guarantee future results.
Risk: Volatility and Drawdowns
IBRN has been the more volatile fund, with annualized monthly volatility of 21.4% compared with 14.1% for VOO. Lower volatility generally means a smoother ride, though it often comes with lower long-run returns.
The deepest peak-to-trough decline in our data was -35.4% for IBRN and -34.3% for VOO. Drawdown depth is worth weighing if you expect to sell during market stress rather than ride it out.
The two funds' monthly returns correlate at 0.42. They move independently enough that combining them can meaningfully diversify a portfolio.
Fees and Cost Over Time
IBRN charges 0.47% per year while VOO charges 0.03%. On a $10,000 position that is $47 vs $3 annually, a gap of $44 per year that compounds over a long holding period. On income, IBRN currently yields 0.82% against 1.09% for VOO.
Holdings Overlap
IBRN and VOO share 1 holdings out of 574 unique holdings combined, representing a 0.1% weight overlap.
Moderate overlap means holding both could provide meaningful diversification benefits.
Top Shared Holdings
| Stock | Weight in IBRN | Weight in VOO | Difference |
|---|---|---|---|
| BIIB | 3.88% | 0.05% | 3.83% |
Frequently Asked Questions
Which is cheaper, IBRN or VOO?
IBRN has an expense ratio of 0.47% while VOO charges 0.03%. VOO is the cheaper option. On a $10,000 investment, that is $44 per year of difference.
Which performed better, IBRN or VOO?
Over the past year IBRN returned +70.47% vs +23.01% for VOO, so IBRN leads on 1-year performance. Over the longest common window we track (4 years), IBRN annualized +12.93% vs +13.57% for VOO. Past performance does not guarantee future results.
Which is riskier, IBRN or VOO?
IBRN has been the more volatile fund at 21.4% annualized versus 14.1% for VOO. Worst drawdown: IBRN -35.4% vs VOO -34.3%.
Should I hold both IBRN and VOO?
IBRN and VOO have a monthly-return correlation of 0.42, so combining them can provide real diversification depending on your allocation goals.
What is the holdings overlap between IBRN and VOO?
IBRN and VOO share 1 common holdings with a 0.1% weight overlap. Combined, they hold 574 unique securities.
Which pays a higher dividend, IBRN or VOO?
IBRN yields 0.82% while VOO yields 1.09%, so VOO currently pays the higher dividend yield.
Popular ETF Comparisons
Get Full ETF Analytics
Access complete holdings data, overlap analysis, screener tools, and more with FundXLS.