Mutual Funds Holding BIIB

Patient Opportunity Trust Class R

Alger Mid Cap Focus Fund Class I

Alger Mid Cap Focus Fund Class A

Alger Mid Cap Focus Fund Class Y

Vanguard PRIMECAP Fund Admiral Shares

Rydex Biotechnology Fund Class A

Rydex Biotechnology Fund Class H

PRIMECAP Odyssey Aggressive Growth Fund

AlphaCentric Life Sciences and Healthcare Fund Class C

FullerThaler Behavioral Mid-Cap Equity Fund Institutional Class

Vanguard Capital Opportunity Fund

Causeway Global Value Fund Institutional Class

Victory Pioneer Disciplined Value Fund Class C

Victory Pioneer Disciplined Value Fund Class Y

Victory Pioneer Disciplined Value Fund Class R

Transamerica Mid Cap Value Opportunities Fund Class A

Transamerica Mid Cap Value Opportunities Fund Class R6

Transamerica Mid Cap Value Opportunities Fund Class R4

Transamerica Mid Cap Value Opportunities Fund Class I3

Vanguard Health Care Fund

Victory Pioneer Mid Cap Value Fund Class A

Victory Pioneer Mid Cap Value Fund Class Y

Victory Pioneer Core Equity Fund Class C

Victory Pioneer Core Equity Fund Class Y

BlackRock Health Sciences Opportunity Service Class

BlackRock Health Sciences Opportunity Fund Investor C Class

BlackRock Health Sciences Opportunities Portfolio Class R Shares

American Beacon Man Large Cap Value Fund Institutional Class

American Beacon Man Large Cap Value Fund Class C

American Beacon Man Large Cap Value Fund Y Class

Hartford Healthcare HLS Fund Class IB

The Hartford Healthcare Fund Class F

The Hartford Healthcare Fund Class I

The Hartford Healthcare Fund Cl R3

The Hartford Healthcare Fund Class R6

Hartford Healthcare HLS Fund Class IA

Biotechnology UltraSector ProFund

Brown Advisory Intermediate Income Fund Investor Shares

Fidelity Select Pharmaceuticals Portfolio

Fidelity Advisor Healthy Future Fund Class C

Fidelity Advisor Healthy Future Fund Class I

Impax Global Women's Leadership Fund Investor Class

DWS Health and Wellness Fund Class S

DWS Health and Wellness Fund Class C

Transamerica Small/Mid Cap Value Fund Class C

Transamerica Small/Mid Cap Value Fund Class R6

Transamerica Small/Mid Cap Value Fund Class I

Nomura Healthcare Fund Class A

Nomura Healthcare Fund Class R

S&P 500 Pure Value Fund Class C

Boston Partners Global Equity Fund Institutional Class

MFS Blended Research Mid Cap Equity Fund Class B

MFS Blended Research Mid Cap Equity Fund Class I

MFS Blended Research Mid Cap Equity Fund Class R2

MFS Blended Research Mid Cap Equity Fund Class R4

MFS Blended Research Mid Cap Equity Fund Class R6

Rydex Health Care Fund Class A

Rydex Health Care Fund Class C

JPMorgan Large Cap Value Fund Class R6

JPMorgan Large Cap Value Fund Class R2

JPMorgan Large Cap Value Fund Class R4

JPMorgan Large Cap Value Fund Class C

John Hancock Disciplined Value Mid Cap Fund Class I

John Hancock Disciplined Value Mid Cap Fund Class R6

John Hancock Disciplined Value Mid Cap Fund Class R2

Alger Dynamic Opportunities Fund Class Z

Leuthold Core Investment Fund Inst Cl

Alger Capital Appreciation Portfolio Class I2

AQR Style Premia Alternative Fund Class R6

Alger Focus Equity Fund Class A

Alger Focus Equity Fund Class Y

Alger Focus Equity Fund Class Z

Fidelity Women's Leadership Fund Class A

Fidelity Women's Leadership Fund Class M

Fidelity Women's Leadership Fund

Fidelity Advisor Sustainable US Equity Fund

Fidelity Advisor Sustainable US Equity Fund Class C

Fidelity Advisor Sustainable US Equity Fund Class I

Alger Responsible Investing Fund Class C

Alger Responsible Investing Fund Class Z

Alger Spectra Fund Class I

Alger Spectra Fund Class Z

Alger Responsible Investing Fund Class A

NAA Opportunity Fund Class C

Morgan Stanley Institutional Fund Advantage Portfolio Class R6

Morgan Stanley Institutional Fund Advantage Portfolio Class A

Morgan Stanley Institutional Fund Advantage Portfolio Class C

Vanguard Mid-Cap Value Index Fund Investor Shares

Alger Capital Appreciation Fund Class A

Alger Capital Appreciation Institutional Fund Class Y

Alger Capital Appreciation Institutional Fund Class Z-2

Alger Capital Appreciation Fund Class C

MFS Mid Cap Value Fund Class R2

MFS Mid Cap Value Fund Class C

MFS Mid Cap Value Fund Class R3

MFS Mid Cap Value Fund Class R6

Optimum Small-Mid Cap Growth Fund Class A

Optimum Small-Mid Cap Growth Fund Class I

AQR Alternative Risk Premia Fund Class I

Vanguard Health Care Index Fund admiral class

DWS Enhanced Core Equity Fund Class I

DWS Enhanced Core Equity Fund Class R

DWS Enhanced Core Equity Fund Class R6

Empower T. Rowe Price Mid Cap Growth Fund Institutional Class

T. Rowe Price Institutional Mid-Cap Equity Growth Fund

T. Rowe Price Mid-Cap Growth Portfolio

T. Rowe Price Mid-Cap Growth Fund Class I

T. Rowe Price Mid-Cap Growth Fund Class z

Fidelity Fund Class K

Health Care UltraSector ProFund Investor

BlackRock Advantage Large Cap Value V.I. Fund Class I

Fidelity Puritan Fund Class K

AQR LSE Fusion Fund Class I

AQR LSE Fusion Fund Class R6

Franklin US Large Cap Equity Fund Class I

VALIC Company I Mid Cap Value Fund

JPMorgan Research Market Neutral Fund Class C

BlackRock Advantage Large Cap Value Fund Institutional Class

BlackRock Advantage Large Cap Value Fund Class A

BlackRock Advantage Large Cap Value Fund Class R

PGIM Quant Solutions Large-Cap Core Fund Class Z

PGIM Quant Solutions Large-Cap Core Fund Class C

MassMutual Mid Cap Growth Fund Class A

MassMutual Mid Cap Growth Fund Class R3

MassMutual Mid Cap Growth Fund Class I

MassMutual Mid Cap Growth Fund Administrative Class

BlackRock Advantage Large Cap Core V.I. Fund Class III

BlackRock Advantage Large Cap Core V.I. Fund Class I

T. Rowe Price Equity Income Portfolio

Vanguard Mid-Cap Index Fund Investor Class

Vanguard Mid-Cap Index Fund Institutional Plus Class

Schwab Health Care Fund

Calvert US Large Cap Value Responsible Index Fund Class I

Calvert US Large Cap Value Responsible Index Fund Class R6

Calvert US Mid Cap Core Responsible Index Class A

Fidelity Mid Cap Value Index Fund

John Hancock Variable Insurance Trust Equity Income Trust Series I

T. Rowe Price Equity Income Fund Advisor Class

AQR MS Fusion Fund Class I

AQR MS Fusion Fund Class R6

T. Rowe Price Equity Income Fund-R Class

Fidelity Advisor Diversified Stock Fund Class O

Fidelity Advisor Diversified Stock Fund Class M

Fidelity Advisor Diversified Stock Fund Class A

Fidelity Low-Priced Stock Fund Class A

Fidelity Low-Priced Stock Fund Class I

Fidelity Low-Priced Stock Fund Class Z

Fidelity Low-Priced Stock Fund Class K

Gotham Large Value Fund Institutional Class

John Hancock Funds II Equity Income Fund Class C

SIMT Mid-Cap Fund Class F

SIMT Mid-Cap Fund Class I

Fidelity Advisor Multi-Asset Income Fund Class M

Fidelity Advisor Multi-Asset Income Fund

Fidelity Advisor Multi-Asset Income Fund Class C

SIMT Large Cap Growth Fund Class Y

Vanguard US Multifactor Fund Admiral Shares

Fidelity Advisor Health Care Fund Class A

Fidelity Advisor Health Care Fund Class C

Fidelity Advisor Health Care Fund Class Z

Horizon Multi-Factor US Equity Fund Advisor class

Fidelity Contrafund

Fidelity Mid-Cap Stock K6 Fund Class K6

GuideStone Funds Equity Index Fund Investor Class

Voya Russell Mid Cap Index Portfolio Initial

Voya Russell Mid Cap Index Portfolio S2

Voya VACS Index Series MC Portfolio

Column Mid Cap Select Fund

Fidelity Mid-Cap Stock Fund Class K

Fidelity Mid-Cap Stock Fund Class A

Fidelity Mid-Cap Stock Fund Class I

Fidelity Mid-Cap Stock Fund Class Z

Fidelity SAI US Low Volatility Index Fund

AQR Long-Short Equity Fund Class I

Schwab US Mid-Cap Index Fund

Invesco Equally-Weighted S&P 500 Fund Class C

Invesco Equally-Weighted S&P 500 Fund Class Y

Wilshire Large Company Growth Portfolio Institutional Class

iShares Russell Mid-Cap Index Fund Investor A Class

Columbia Multi-Manager Directional Alternative Strategies Fund Institutional Class

Gotham Enhanced S&P 500 Index Fund Institutional Class