SBIO vs VOO
ALPS Medical Breakthroughs ETF vs Vanguard S&P 500 ETF
Quick Verdict
VOO has a lower expense ratio. SBIO delivered stronger 1-year returns. VOO offers more diversification with 505 holdings.
Side-by-Side Comparison
| Metric | SBIO | VOO | Winner |
|---|---|---|---|
| Expense Ratio | 0.50% | 0.03% | |
| AUM | $202M | $979.0B | |
| Dividend Yield | 4.05% | 1.09% | |
| Holdings | 87 | 509 | |
| YTD Return | +33.77% | +13.44% | |
| 1Y Return | +104.83% | +22.62% | |
| 3Y Return (annualized) | +32.41% | +21.47% | |
| 5Y Return (annualized) | +9.72% | +13.27% | |
| Volatility (annualized) | 29.6% | 14.1% | |
| Max Drawdown | -63.1% | -34.3% | |
| Fund Family | ALPS Advisors | Vanguard (US) | |
| Category | Equity | Equity | |
| Inception | Dec 30, 2014 | Sep 7, 2010 |
SBIO vs VOO Performance
ALPS Medical Breakthroughs ETF (SBIO) is a ETF from ALPS Advisors and Vanguard S&P 500 ETF (VOO) is a ETF from Vanguard (US). Over the past year SBIO returned +104.83% while VOO returned +22.62%. Year to date, SBIO is up 33.77% versus a gain of 13.44% for VOO.
Over three years, SBIO compounded at +32.41% per year against +21.47% for VOO; over five years the annualized figures are +9.72% and +13.27% respectively. Across the full 12-year window we track, VOO has the edge at +13.55% annualized vs +9.71%. Past performance does not guarantee future results.
Risk: Volatility and Drawdowns
SBIO has been the more volatile fund, with annualized monthly volatility of 29.6% compared with 14.1% for VOO. Lower volatility generally means a smoother ride, though it often comes with lower long-run returns.
The deepest peak-to-trough decline in our data was -63.1% for SBIO and -34.3% for VOO. Drawdown depth is worth weighing if you expect to sell during market stress rather than ride it out.
The two funds' monthly returns correlate at 0.52. They move independently enough that combining them can meaningfully diversify a portfolio.
Fees and Cost Over Time
SBIO charges 0.50% per year while VOO charges 0.03%. On a $10,000 position that is $50 vs $3 annually, a gap of $47 per year that compounds over a long holding period. On income, SBIO currently yields 4.05% against 1.09% for VOO.
Holdings Overlap
SBIO and VOO share 0 holdings out of 610 unique holdings combined, representing a 0.0% weight overlap.
Moderate overlap means holding both could provide meaningful diversification benefits.
Frequently Asked Questions
Which is cheaper, SBIO or VOO?
SBIO has an expense ratio of 0.50% while VOO charges 0.03%. VOO is the cheaper option. On a $10,000 investment, that is $47 per year of difference.
Which performed better, SBIO or VOO?
Over the past year SBIO returned +104.83% vs +22.62% for VOO, so SBIO leads on 1-year performance. Over the longest common window we track (12 years), SBIO annualized +9.71% vs +13.55% for VOO. Past performance does not guarantee future results.
Which is riskier, SBIO or VOO?
SBIO has been the more volatile fund at 29.6% annualized versus 14.1% for VOO. Worst drawdown: SBIO -63.1% vs VOO -34.3%.
Should I hold both SBIO and VOO?
SBIO and VOO have a monthly-return correlation of 0.52, so combining them can provide real diversification depending on your allocation goals.
What is the holdings overlap between SBIO and VOO?
SBIO and VOO share 0 common holdings with a 0.0% weight overlap. Combined, they hold 610 unique securities.
Which pays a higher dividend, SBIO or VOO?
SBIO yields 4.05% while VOO yields 1.09%, so SBIO currently pays the higher dividend yield.
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