SPY vs TDNA
State Street SPDR S&P 500 ETF Trust vs T. Rowe Price Biotech ETF
Which is better, SPY or TDNA?
Large Cap Blend against Small Cap Growth.
SPY has a lower expense ratio. TDNA is less concentrated, with 27.8% of the fund in its ten largest positions against 38.2%.
MarketXLS is not an investment adviser. This comparison is generated automatically from market data and is for information only. A Best mark means the better reading on that one measure, not a recommendation to buy.
Side-by-Side Comparison
| Metric | SPY | TDNA |
|---|---|---|
| Expense Ratio | 0.09%Best | 0.55% |
| AUM | $823.2B | $9M |
| Dividend Yield | 0.99% | 0.00% |
| Holdings | 1,515 | 85 |
| YTD Return | +11.48%Best | -2.35% |
| 1Y Return | +12.36% | - |
| 3Y Return (annualized) | +23.30% | - |
| 5Y Return (annualized) | +11.94% | - |
| Top 10 Weight | 38.2% | 27.8%Best |
| Fund Family | State Street Investment Management | T.Rowe Price |
| Category | Equity | Equity |
| Style | Large Cap Blend | Small Cap Growth |
| Inception | Jan 22, 1993 | Sep 16, 2026 |
Not shown on this pair: Volatility (annualized), Max Drawdown, $10,000 over the window.
SPY vs TDNA growth
Month-end closes. Both lines start at 0% in the first month shown, so the gap between them is the difference in growth across that window. The full view is available from the range buttons; it is not the opening view here because over the whole period one of these two funds moves so much further than the other that its line would sit flat on the axis.
SPY vs TDNA Performance
State Street SPDR S&P 500 ETF Trust (SPY) is an ETF from State Street Investment Management and T. Rowe Price Biotech ETF (TDNA) is an ETF from T.Rowe Price. Year to date, SPY is up 11.48% versus a loss of 2.35% for TDNA.
Past performance does not guarantee future results.
Fees and Cost Over Time
SPY charges 0.09% per year while TDNA charges 0.55%. On a $10,000 position that is $9 vs $55 annually, a gap of $46 per year that compounds over a long holding period. On income, SPY currently yields 0.99% against 0.00% for TDNA.
Holdings Overlap
1.1% of SPY's money is in holdings TDNA also owns. 8.4% of TDNA's money is in holdings SPY also owns.
TDNA and SPY share little of their money.
7 positions in common, counted across the 504 positions we hold weights for in SPY and 85 in TDNA, against full books of 1,515 and 85.
What only one of them owns
Our book lists 73 positions for TDNA that do not appear in our book for SPY (81.1% of the fund), and 490 for SPY that do not appear in TDNA (98.2%).
Some of those will be the same company recorded under a different code in one of the two books, so the real difference in what you would own is no larger than this and may be smaller. We do not name the individual positions here for that reason.
Top Shared Holdings
| Stock | Weight in SPY | Weight in TDNA | Difference |
|---|---|---|---|
| VRTXNvaesrtex Pharmaceuticals Inc | 0.20% | 2.25% | 2.05% |
| MRNAModerna therapeutics | 0.08% | 1.90% | 1.82% |
| AMGNAmgen Inc. | 0.31% | 0.90% | 0.59% |
| GILDGilead Sciences | 0.28% | 0.84% | 0.56% |
| BIIBBiogen Inc. Com | 0.05% | 1.03% | 0.98% |
| REGNRegeneron Pharmaceuticals, Inc. | 0.12% | 0.74% | 0.62% |
| INCYIncyte Corporation Ltd. | 0.03% | 0.74% | 0.71% |
You are not choosing between two funds in isolation.
Whichever of SPY and TDNA you pick has to sit alongside everything else you own. Add the rest and see what the combination actually holds.
Free for up to 10 holdings. No account needed.
Frequently Asked Questions
Which is cheaper, SPY or TDNA?
SPY has an expense ratio of 0.09% while TDNA charges 0.55%. SPY is the cheaper option, by $46 a year on a $10,000 investment.
What is the holdings overlap between SPY and TDNA?
8.4% of TDNA's money is in holdings SPY also owns. 8.4% of TDNA's is in holdings SPY also owns. They hold 7 positions in common, counted across the 504 positions we hold weights for in SPY and 85 in TDNA.
Which pays a higher dividend, SPY or TDNA?
SPY yields 0.99% while TDNA yields 0.00%, so SPY currently pays the higher dividend yield.
Is TDNA better than SPY?
SPY has a lower expense ratio. TDNA is less concentrated, with 27.8% of the fund in its ten largest positions against 38.2%. Which one suits a particular account depends on what it is for. This is information, not a recommendation.