TDNA vs VTI
T. Rowe Price Biotech ETF vs Vanguard Morningstar Total Stock Market ETF
Which is better, TDNA or VTI?
Small Cap Growth against Large Cap Blend.
VTI has a lower expense ratio. TDNA is less concentrated, with 28.7% of the fund in its ten largest positions against 34.6%.
MarketXLS is not an investment adviser. This comparison is generated automatically from market data and is for information only. A Best mark means the better reading on that one measure, not a recommendation to buy.
Side-by-Side Comparison
| Metric | TDNA | VTI |
|---|---|---|
| Expense Ratio | 0.55% | 0.03%Best |
| AUM | $11M | $689.2B |
| Dividend Yield | 0.00% | 1.06% |
| Holdings | 174 | 3,542 |
| YTD Return | +0.43% | +12.23%Best |
| 1Y Return | - | +12.74% |
| 3Y Return (annualized) | - | +21.44% |
| 5Y Return (annualized) | - | +10.83% |
| Top 10 Weight | 28.7%Best | 34.6% |
| Fund Family | T.Rowe Price | Vanguard (US) |
| Category | Equity | Equity |
| Style | Small Cap Growth | Large Cap Blend |
| Inception | Sep 16, 2026 | May 24, 2001 |
Not shown on this pair: Volatility (annualized), Max Drawdown, $10,000 over the window.
TDNA vs VTI growth
Month-end closes. Both lines start at 0% in the first month shown, so the gap between them is the difference in growth across that window. The full view is available from the range buttons; it is not the opening view here because over the whole period one of these two funds moves so much further than the other that its line would sit flat on the axis.
TDNA vs VTI Performance
T. Rowe Price Biotech ETF (TDNA) is an ETF from T.Rowe Price and Vanguard Morningstar Total Stock Market ETF (VTI) is an ETF from Vanguard (US). Year to date, TDNA is up 0.43% versus a gain of 12.23% for VTI.
Past performance does not guarantee future results.
Fees and Cost Over Time
TDNA charges 0.55% per year while VTI charges 0.03%. On a $10,000 position that is $55 vs $3 annually, a gap of $52 per year that compounds over a long holding period. On income, TDNA currently yields 0.00% against 1.06% for VTI.
Holdings Overlap
91.1% of TDNA's money is in holdings VTI also owns. 1.6% of VTI's money is in holdings TDNA also owns.
Most of TDNA is already inside VTI. Owning both mostly buys the same companies twice.
79 positions in common, counted across the 85 positions we hold weights for in TDNA and 3,464 in VTI, against full books of 174 and 3,542.
What only one of them owns
Our book lists 1,088 positions for VTI that do not appear in our book for TDNA (95.3% of the fund), and 2 for TDNA that do not appear in VTI (0.8%).
Some of those will be the same company recorded under a different code in one of the two books, so the real difference in what you would own is no larger than this and may be smaller. We do not name the individual positions here for that reason.
Top Shared Holdings
| Stock | Weight in TDNA | Weight in VTI | Difference |
|---|---|---|---|
| KYMRKymera Therapeutics Inccommon Stock | 4.20% | 0.01% | 4.19% |
| NTRANatera Inc | 2.51% | 0.08% | 2.43% |
| MRNAModerna Inc | 2.43% | 0.09% | 2.34% |
| VRTXVertex Pharmaceuticals Inc | 2.34% | 0.18% | 2.16% |
| KODKodiak Sciences Inc | 2.49% | 0.01% | 2.48% |
| RVMDRevolution Medicines Inc | 2.44% | 0.06% | 2.38% |
| PCVXVaxcyte Inc | 2.46% | 0.01% | 2.45% |
| INSMInsmed Inc | 2.42% | 0.03% | 2.39% |
| UTHRUnited Therapeutics Corp | 2.38% | 0.03% | 2.35% |
| ALNYAlnylam Pharmaceuticals Inc. | 1.96% | 0.05% | 1.91% |
91.1% of TDNA is already inside VTI.
You probably hold more than these two. Add the rest and see how much of the whole book is the same companies twice.
Free for up to 10 holdings. No account needed.
Frequently Asked Questions
Which is cheaper, TDNA or VTI?
TDNA has an expense ratio of 0.55% while VTI charges 0.03%. VTI is the cheaper option, by $52 a year on a $10,000 investment.
What is the holdings overlap between TDNA and VTI?
91.1% of TDNA's money is in holdings VTI also owns. 1.6% of VTI's is in holdings TDNA also owns. They hold 79 positions in common, counted across the 85 positions we hold weights for in TDNA and 3,464 in VTI.
Which pays a higher dividend, TDNA or VTI?
TDNA yields 0.00% while VTI yields 1.06%, so VTI currently pays the higher dividend yield.
Is VTI better than TDNA?
VTI has a lower expense ratio. TDNA is less concentrated, with 28.7% of the fund in its ten largest positions against 34.6%. Which one suits a particular account depends on what it is for. This is information, not a recommendation.