TDNA vs VOO
T. Rowe Price Biotech ETF vs Vanguard S&P 500 ETF
Which is better, TDNA or VOO?
Small Cap Growth against Large Cap Blend.
VOO has a lower expense ratio. TDNA is less concentrated, with 27.8% of the fund in its ten largest positions against 37.9%.
MarketXLS is not an investment adviser. This comparison is generated automatically from market data and is for information only. A Best mark means the better reading on that one measure, not a recommendation to buy.
Side-by-Side Comparison
| Metric | TDNA | VOO |
|---|---|---|
| Expense Ratio | 0.55% | 0.03%Best |
| AUM | $9M | $1.0T |
| Dividend Yield | 0.00% | 1.06% |
| Holdings | 85 | 506 |
| YTD Return | -1.25% | +13.55%Best |
| 1Y Return | - | +13.22% |
| 3Y Return (annualized) | - | +24.40% |
| 5Y Return (annualized) | - | +12.44% |
| Top 10 Weight | 27.8%Best | 37.9% |
| Fund Family | T.Rowe Price | Vanguard (US) |
| Category | Equity | Equity |
| Style | Small Cap Growth | Large Cap Blend |
| Inception | Sep 16, 2026 | Sep 7, 2010 |
Not shown on this pair: Volatility (annualized), Max Drawdown, $10,000 over the window.
TDNA vs VOO growth
Month-end closes. Both lines start at 0% in the first month shown, so the gap between them is the difference in growth across that window. The full view is available from the range buttons; it is not the opening view here because over the whole period one of these two funds moves so much further than the other that its line would sit flat on the axis.
TDNA vs VOO Performance
T. Rowe Price Biotech ETF (TDNA) is an ETF from T.Rowe Price and Vanguard S&P 500 ETF (VOO) is an ETF from Vanguard (US). Year to date, TDNA is down 1.25% versus a gain of 13.55% for VOO.
Past performance does not guarantee future results.
Fees and Cost Over Time
TDNA charges 0.55% per year while VOO charges 0.03%. On a $10,000 position that is $55 vs $3 annually, a gap of $52 per year that compounds over a long holding period. On income, TDNA currently yields 0.00% against 1.06% for VOO.
Holdings Overlap
8.4% of TDNA's money is in holdings VOO also owns. 1.1% of VOO's money is in holdings TDNA also owns.
TDNA and VOO share little of their money.
7 positions in common, counted across the 85 positions we hold weights for in TDNA and 504 in VOO, against full books of 85 and 506.
What only one of them owns
Our book lists 492 positions for VOO that do not appear in our book for TDNA (98.6% of the fund), and 73 for TDNA that do not appear in VOO (81.1%).
Some of those will be the same company recorded under a different code in one of the two books, so the real difference in what you would own is no larger than this and may be smaller. We do not name the individual positions here for that reason.
Top Shared Holdings
| Stock | Weight in TDNA | Weight in VOO | Difference |
|---|---|---|---|
| VRTXNvaesrtex Pharmaceuticals Inc | 2.25% | 0.21% | 2.04% |
| MRNAModerna therapeutics | 1.90% | 0.07% | 1.83% |
| AMGNAmgen Inc. | 0.90% | 0.35% | 0.55% |
| GILDGilead Sciences | 0.84% | 0.27% | 0.57% |
| BIIBBiogen Inc. Com | 1.03% | 0.05% | 0.98% |
| REGNRegeneron Pharmaceuticals, Inc. | 0.74% | 0.12% | 0.62% |
| INCYIncyte Corporation Ltd. | 0.74% | 0.03% | 0.71% |
You are not choosing between two funds in isolation.
Whichever of TDNA and VOO you pick has to sit alongside everything else you own. Add the rest and see what the combination actually holds.
Free for up to 10 holdings. No account needed.
Frequently Asked Questions
Which is cheaper, TDNA or VOO?
TDNA has an expense ratio of 0.55% while VOO charges 0.03%. VOO is the cheaper option, by $52 a year on a $10,000 investment.
What is the holdings overlap between TDNA and VOO?
8.4% of TDNA's money is in holdings VOO also owns. 1.1% of VOO's is in holdings TDNA also owns. They hold 7 positions in common, counted across the 85 positions we hold weights for in TDNA and 504 in VOO.
Which pays a higher dividend, TDNA or VOO?
TDNA yields 0.00% while VOO yields 1.06%, so VOO currently pays the higher dividend yield.
Is VOO better than TDNA?
VOO has a lower expense ratio. TDNA is less concentrated, with 27.8% of the fund in its ten largest positions against 37.9%. Which one suits a particular account depends on what it is for. This is information, not a recommendation.