CANC vs VOO
Tema Oncology ETF vs Vanguard S&P 500 ETF
Quick Verdict
VOO has a lower expense ratio. CANC delivered stronger 1-year returns. VOO offers more diversification with 505 holdings.
Side-by-Side Comparison
| Metric | CANC | VOO | Winner |
|---|---|---|---|
| Expense Ratio | 0.75% | 0.03% | |
| AUM | $196M | $979.0B | |
| Dividend Yield | 0.05% | 1.09% | |
| Holdings | 56 | 509 | |
| YTD Return | +24.46% | +13.44% | |
| 1Y Return | +69.85% | +22.62% | |
| 3Y Return (annualized) | +22.28% | +21.47% | |
| 5Y Return (annualized) | - | +13.27% | |
| Volatility (annualized) | 19.3% | 14.1% | |
| Max Drawdown | -26.1% | -34.3% | |
| Fund Family | Tema Global Limited | Vanguard (US) | |
| Category | Equity | Equity | |
| Inception | Aug 15, 2023 | Sep 7, 2010 |
CANC vs VOO Performance
Tema Oncology ETF (CANC) is a ETF from Tema Global Limited and Vanguard S&P 500 ETF (VOO) is a ETF from Vanguard (US). Over the past year CANC returned +69.85% while VOO returned +22.62%. Year to date, CANC is up 24.46% versus a gain of 13.44% for VOO.
Over three years, CANC compounded at +22.28% per year against +21.47% for VOO. Across the full 3-year window we track, CANC has the edge at +22.28% annualized vs +13.55%. Past performance does not guarantee future results.
Risk: Volatility and Drawdowns
CANC has been the more volatile fund, with annualized monthly volatility of 19.3% compared with 14.1% for VOO. Lower volatility generally means a smoother ride, though it often comes with lower long-run returns.
The deepest peak-to-trough decline in our data was -26.1% for CANC and -34.3% for VOO. Drawdown depth is worth weighing if you expect to sell during market stress rather than ride it out.
The two funds' monthly returns correlate at 0.45. They move independently enough that combining them can meaningfully diversify a portfolio.
Fees and Cost Over Time
CANC charges 0.75% per year while VOO charges 0.03%. On a $10,000 position that is $75 vs $3 annually, a gap of $72 per year that compounds over a long holding period. On income, CANC currently yields 0.05% against 1.09% for VOO.
Holdings Overlap
CANC and VOO share 8 holdings out of 554 unique holdings combined, representing a 4.4% weight overlap.
Moderate overlap means holding both could provide meaningful diversification benefits.
Frequently Asked Questions
Which is cheaper, CANC or VOO?
CANC has an expense ratio of 0.75% while VOO charges 0.03%. VOO is the cheaper option. On a $10,000 investment, that is $72 per year of difference.
Which performed better, CANC or VOO?
Over the past year CANC returned +69.85% vs +22.62% for VOO, so CANC leads on 1-year performance. Over the longest common window we track (3 years), CANC annualized +22.28% vs +13.55% for VOO. Past performance does not guarantee future results.
Which is riskier, CANC or VOO?
CANC has been the more volatile fund at 19.3% annualized versus 14.1% for VOO. Worst drawdown: CANC -26.1% vs VOO -34.3%.
Should I hold both CANC and VOO?
CANC and VOO have a monthly-return correlation of 0.45, so combining them can provide real diversification depending on your allocation goals.
What is the holdings overlap between CANC and VOO?
CANC and VOO share 8 common holdings with a 4.4% weight overlap. Combined, they hold 554 unique securities.
Which pays a higher dividend, CANC or VOO?
CANC yields 0.05% while VOO yields 1.09%, so VOO currently pays the higher dividend yield.
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