CANC vs VOO
Tema Oncology ETF vs Vanguard S&P 500 ETF
Which is better, CANC or VOO?
Each has led over a different period.
VOO has a lower expense ratio. CANC led over 1Y and 3Y, VOO over the full window. VOO is less concentrated, with 37.6% of the fund in its ten largest positions against 39.4%.
MarketXLS is not an investment adviser. This comparison is generated automatically from market data and is for information only. A Best mark means the better reading on that one measure, not a recommendation to buy.
Side-by-Side Comparison
| Metric | CANC | VOO |
|---|---|---|
| Expense Ratio | 0.75% | 0.03%Best |
| AUM | $213M | $997.4B |
| Dividend Yield | 0.05% | 1.04% |
| Holdings | 58 | 509 |
| YTD Return | +21.75%Best | +14.14% |
| 1Y Return | +53.62%Best | +17.31% |
| 3Y Return (annualized) | +24.64%Best | +23.16% |
| 5Y Return (annualized) | - | +13.85% |
| Volatility (annualized) | 19.2% | 12.8%Best |
| Max Drawdown | -26.1% | -18.7%Best |
| $10,000 over 3.1 years | $17,845 | $18,210Best |
| Top 10 Weight | 39.4% | 37.6%Best |
| Fund Family | Tema Global Limited | Vanguard (US) |
| Category | Equity | Equity |
| Style | Large Cap Blend | Large Cap Blend |
| Inception | Aug 15, 2023 | Sep 7, 2010 |
Volatility and max drawdown, and the $10,000 over 3.1 years row, are measured over the window both funds cover: Aug 15, 2023 to Sep 21, 2026 (3.1 years).
CANC vs VOO growth
Month-end closes. Both lines start at 0% in the first month shown, so the gap between them is the difference in growth across that window. The full view covers the 3.1 years both funds cover.
CANC vs VOO Performance
Tema Oncology ETF (CANC) is an ETF from Tema Global Limited and Vanguard S&P 500 ETF (VOO) is an ETF from Vanguard (US). Over the past year CANC returned +53.62% while VOO returned +17.31%. Year to date, CANC is up 21.75% versus a gain of 14.14% for VOO.
Over three years, CANC compounded at +24.64% per year against +23.16% for VOO.
Past performance does not guarantee future results.
Risk: Volatility and Drawdowns
CANC has been the more volatile fund, with annualized monthly volatility of 19.2% compared with 12.8% for VOO. Lower volatility generally means a smoother ride, though it often comes with lower long-run returns.
The deepest peak-to-trough decline in our data was -26.1% for CANC and -18.7% for VOO. Drawdown depth is what each fund did in the worst stretch of the window measured above.
The two funds' monthly returns correlate at 0.44. They move together some of the time, and apart the rest.
Fees and Cost Over Time
CANC charges 0.75% per year while VOO charges 0.03%. On a $10,000 position that is $75 vs $3 annually, a gap of $72 per year that compounds over a long holding period. On income, CANC currently yields 0.05% against 1.04% for VOO.
Holdings Overlap
22.6% of CANC's money is in holdings VOO also owns. 4.4% of VOO's money is in holdings CANC also owns.
CANC and VOO share little of their money.
8 positions in common, counted across the 59 positions we hold weights for in CANC and 494 in VOO, against full books of 58 and 509.
What only one of them owns
Our book lists 479 positions for VOO that do not appear in our book for CANC (94.8% of the fund), and 42 for CANC that do not appear in VOO (62.5%).
Some of those will be the same company recorded under a different code in one of the two books, so the real difference in what you would own is no larger than this and may be smaller. We do not name the individual positions here for that reason.
Top Shared Holdings
| Stock | Weight in CANC | Weight in VOO | Difference |
|---|---|---|---|
| LLYEli Lilly & Co. | 4.37% | 1.41% | 2.96% |
| MRKMerck & Company Inc | 4.62% | 0.50% | 4.12% |
| JNJJohnson & Johnson - Common | 3.16% | 0.96% | 2.20% |
| ABBVAbbvie Inc. | 3.35% | 0.69% | 2.66% |
| BMYBristol-Myers Squibb Co. | 3.57% | 0.21% | 3.36% |
| AMGNAmgen Inc. | 2.09% | 0.32% | 1.77% |
| GILDGilead Sciences | 1.03% | 0.25% | 0.78% |
| MRNAModerna therapeutics | 0.37% | 0.03% | 0.34% |
22.6% of CANC is already inside VOO.
You probably hold more than these two. Add the rest and see how much of the whole book is the same companies twice.
Free for up to 10 holdings. No account needed.
Frequently Asked Questions
Which is cheaper, CANC or VOO?
CANC has an expense ratio of 0.75% while VOO charges 0.03%. VOO is the cheaper option, by $72 a year on a $10,000 investment.
Which performed better, CANC or VOO?
Over the past year CANC returned +53.62% vs +17.31% for VOO, so CANC leads on 1-year performance. Past performance does not guarantee future results. This is information, not a recommendation.
Which is riskier, CANC or VOO?
CANC has been the more volatile fund at 19.2% annualized versus 12.8% for VOO. Worst drawdown: CANC -26.1% vs VOO -18.7%.
Should I hold both CANC and VOO?
CANC and VOO have a monthly-return correlation of 0.44, so their returns are far enough apart for the mix to behave differently from either one alone. This is information, not a recommendation.
What is the holdings overlap between CANC and VOO?
22.6% of CANC's money is in holdings VOO also owns. 4.4% of VOO's is in holdings CANC also owns. They hold 8 positions in common, counted across the 59 positions we hold weights for in CANC and 494 in VOO.
Which pays a higher dividend, CANC or VOO?
CANC yields 0.05% while VOO yields 1.04%, so VOO currently pays the higher dividend yield.
Is VOO better than CANC?
VOO has a lower expense ratio. CANC led over 1Y and 3Y, VOO over the full window. VOO is less concentrated, with 37.6% of the fund in its ten largest positions against 39.4%. Which one suits a particular account depends on what it is for. This is information, not a recommendation.