SBIO ETF largest holding is CRNX at 4.55% as of Aug 14, 2026
ALPS Medical Breakthroughs ETF
CRNX is SBIO's largest holding at 4.55% of the fund as of Aug 14, 2026. SBIO is ALPS Medical Breakthroughs ETF.
| # | Ticker | Name | Weight | Cumulative | Shares | Mkt value | Sector | Industry |
|---|---|---|---|---|---|---|---|---|
| 1 |  C | Crinetics Pharmaceuticals IncHealth Care · Pharmaceuticals | 4.55% | 4.5% | 119,051 | $10.08M | Health Care | Pharmaceuticals |
| 2 |  A | Apogee Therapeutics IncHealth Care · Biotechnology | 4.24% | 8.8% | 69,943 | $9.41M | Health Care | Biotechnology |
| Sector and industry · Pro | ||||||||
| 3 |  O | Oruka Therapeutics Inc Orka | 3.41% | 12.2% | 68,047 | $7.56M | ||
| 4 |  C | Cg Oncology Inc | 3.37% | 15.6% | 99,688 | $7.48M | ||
| 5 |  D | Dianthus Therapeutics Inc | 3.23% | 18.8% | 61,733 | $7.16M | ||
| 6 | — | Xenon Pharmaceuticals Inc. Common Shares | 3.07% | 21.9% | 109,102 | $6.80M | ||
| 7 |  T | Travere Therapeutics Inc | 2.94% | 24.8% | 105,028 | $6.53M | ||
| 8 |  A | Acadia Pharmaceuticals Inc | 2.46% | 27.3% | 193,319 | $5.46M | ||
| 9 |  E | Edgewise Therapeutics Inc. | 2.42% | 29.7% | 121,692 | $5.38M | ||
| 10 |  M | Veradermics Inc | 2.39% | 32.1% | 47,118 | $5.31M | ||
| 11 | — | Definium Therapeutics, Inc. Common Shares | 2.37% | 34.5% | 123,264 | $5.25M | ||
| 12 |  R | Relay Therapeutics Inc | 2.20% | 36.7% | 245,913 | $4.88M | ||
| 13 | — | Dynegy | 2.17% | 38.8% | 186,901 | $4.80M | ||
| 14 |  G | Structure Therapeutics Inc | 1.98% | 40.8% | 80,356 | $4.38M | ||
| 15 |  D | Denali Therapeutics Inc | 1.97% | 42.8% | 179,404 | $4.38M | ||
| 16 |  C | Celldex Therapeutics Inc | 1.68% | 44.5% | 88,573 | $3.72M | ||
| 17 |  M | Mbx Biosciences Inc | 1.66% | 46.1% | 53,719 | $3.68M | ||
| 18 |  I | Ideaya Biosciences Inc | 1.63% | 47.7% | 99,300 | $3.60M | ||
| 19 |  N | Newamsterdam Pharma Company Nv | 1.61% | 49.4% | 132,159 | $3.57M | ||
| 20 |  I | Immunome Inc | 1.57% | 50.9% | 128,020 | $3.48M | ||
| 21 |  I | Disc Medicine Inc | 1.53% | 52.5% | 43,143 | $3.40M | ||
| 22 |  T | Tarsus Pharmaceuticals Inc | 1.51% | 54.0% | 48,520 | $3.36M | ||
| 23 |  Z | Zai Lab Ltd | 1.44% | 55.4% | 123,035 | $3.19M | ||
| 24 |  B | BioCryst Pharmaceuticals Inc. | 1.26% | 56.7% | 287,427 | $2.80M | ||
| 25 |  N | Nektar Therapeutics | 1.26% | 57.9% | 38,234 | $2.79M | ||
| 26 |  V | Viridian Therapeutics Inc | 1.24% | 59.2% | 124,811 | $2.76M | ||
| 27 |  A | Amylyx Pharmaceuticals Inc | 1.23% | 60.4% | 125,775 | $2.72M | ||
| 28 |  S | Sellas Life Sciences Group Inc. | 1.21% | 61.6% | 210,409 | $2.69M | ||
| 29 |  K | Kailera Therapeutics Inc | 1.19% | 62.8% | 146,535 | $2.63M | ||
| 30 |  V | Vera Therapeutics Inc Ser C Pc Pp | 1.16% | 63.9% | 81,167 | $2.57M | ||
| 31 |  M | Mineralys Therapeutics Inc | 1.15% | 65.1% | 99,546 | $2.55M | ||
| 32 |  R | Rapport Therapeutics, Inc. | 1.15% | 66.3% | 53,978 | $2.56M | ||
| 33 |  V | Vericel Corp Ord | 1.15% | 67.4% | 57,647 | $2.55M | ||
| 34 |  P | Palvella Therapeutics Inc | 1.13% | 68.5% | 16,078 | $2.51M | ||
| 35 |  N | Nuvation Bio Inc. | 1.10% | 69.6% | 393,738 | $2.45M | ||
| 36 |  G | Generate Biomedicines Inc | 1.02% | 70.6% | 144,775 | $2.26M | ||
| 37 |  A | Agios Pharmaceuticals Inc | 1.02% | 71.7% | 67,185 | $2.25M | ||
| 38 |  S | Stoke Therapeutics Inc | 0.99% | 72.7% | 70,472 | $2.20M | ||
| 39 |  S | Sarepta Therapeutics Inc | 0.97% | 73.6% | 119,205 | $2.16M | ||
| 40 |  Z | Zenas Biopharma Inc | 0.95% | 74.6% | 71,246 | $2.10M | ||
| 41 |  C | Compass Pathways PLC | 0.93% | 75.5% | 152,641 | $2.05M | ||
| 42 |  L | Lakefront Biotherapeutics Sponsored Adr (1 Ads : 1 Ordinary) | 0.91% | 76.4% | 73,335 | $2.02M | ||
| 43 | — | Immunocore Holdings Plc American Depositary Shares, Each Representing One Ordinary Share, Nominal Value ‚0.002 Per Share | 0.89% | 77.3% | 57,519 | $1.97M | ||
| 44 |  X | Xencor Inc | 0.88% | 78.2% | 83,536 | $1.95M | ||
| 45 |  T | Taysha Gene Therapies Inc | 0.87% | 79.1% | 324,992 | $1.93M | ||
| 46 |  B | Bicara Therapeutics, Inc. | 0.81% | 79.9% | 74,061 | $1.80M | ||
| 47 |  M | Maze Therapeutics Inc | 0.77% | 80.6% | 62,606 | $1.70M | ||
| 48 |  T | Tyra Biosciences Inc | 0.77% | 81.4% | 67,285 | $1.70M | ||
| 49 |  A | Arrivent Biopharma Inc | 0.70% | 82.1% | 52,660 | $1.55M | ||
| 50 |  L | Lb Pharmaceuticals Inc. | 0.70% | 82.8% | 32,543 | $1.55M | ||
| More holdings · Pro | ||||||||
SBIO ETF All Holdings
SBIO holdings total 107 positions. The top 10 holdings account for 32.1% of the fund, led by Crinetics Pharmaceuticals Inc Com at 4.5%, Apogee Therapeutics Inc at 4.2%, Oruka Therapeutics Inc Orka at 3.4%.
SBIO portfolio concentration is moderate, with the top 10 representing 32.1% of total assets. The largest sector exposure is Health Care at 88.0%.
SBIO sectors provide a detailed breakdown. SBIO overlap shows how holdings compare to other funds in your portfolio.
SBIO ETF Holdings
107 of 107 holdings
- 1
Crinetics Pharmaceuticals Inc Com
CRNXHealth Care4.55% - 2
Apogee Therapeutics Inc
APGEHealth Care4.24% - 3
Oruka Therapeutics Inc Orka
ORKAHealth Care3.41% - 4
Cg Oncology Inc
CGONHealth Care3.37% - 5
Dianthus Therapeutics Inc Common Stock USD.001
DNTHHealth Care3.23% - 6
Xenon Pharmaceuticals Inc. Common Shares
XENE:CAHealth Care3.07% - 7
Travere Therapeutics Inc
TVTXHealth Care2.94% - 8
Acadia Pharmaceuticals Inc
ACADHealth Care2.46% - 9
Edgewise Therapeutics Inc.
EWTXHealth Care2.42% - 10
Veradermics Inc
MANEUnknown2.39% - 11
Definium Therapeutics, Inc. Common Shares
DFTX:CAUnknown2.37% - 12
Relay Therapeutics Inc
RLAYHealth Care2.20% - 13
Dynegy
DYNHealth Care2.17% - 14
Structure Therapeutics Inc
GPCRHealth Care1.98% - 15
Denali Therapeutics Inc
DNLIHealth Care1.97% - 16
Celldex Therapeutics Inc
CLDXHealth Care1.68% - 17
Mbx Biosciences Inc
MBXHealth Care1.66% - 18
Ideaya Biosciences Inc
IDYAHealth Care1.63% - 19
Newamsterdam Pharma Company Nv
NAMSHealth Care1.61% - 20
Immunome Inc
IMNMHealth Care1.57% - 21
Disc Medicine Inc
IRONHealth Care1.53% - 22
Tarsus Pharmaceuticals Inc
TARSHealth Care1.51% - 23
Zai Lab Ltd
ZLABHealth Care1.44% - 24
BioCryst Pharmaceuticals Inc.
BCRXHealth Care1.26% - 25
Nektar Therapeutics
NKTRHealth Care1.26% - 26
Viridian Therapeutics Inc
VRDNHealth Care1.24% - 27
Amylyx Pharmaceuticals Inc
AMLXHealth Care1.23% - 28
Sellas Life Sciences Group Inc.
SLSHealth Care1.21% - 29
Kailera Therapeutics Inc
KLRAUnknown1.19% - 30
Vera Therapeutics Inc Ser C Pc Pp
VERAHealth Care1.16% - 31
Mineralys Therapeutics Inc
MLYSHealth Care1.15% - 32
Rapport Therapeutics, Inc.
RAPPHealth Care1.15% - 33
Vericel Corp Ord
VCELHealth Care1.15% - 34
Palvella Therapeutics Inc
PVLAHealth Care1.13% - 35
Nuvation Bio Inc.
NUVBHealth Care1.10% - 36
Generate Biomedicines Inc
GENBUnknown1.02% - 37
Agios Pharmaceuticals Inc
AGIOHealth Care1.02% - 38
Stoke Therapeutics Inc Com
STOKHealth Care0.99% - 39
Sarepta Therapeutics Inc
SRPTHealth Care0.97% - 40
Zenas Biopharma Inc
ZBIOHealth Care0.95% - 41
COMPASS PATHWAYS PLC
CMPSHealth Care0.93% - 42
Lakefront Biotherapeutics Sponsored Adr (1 Ads : 1 Ordinary)
GLPG:BRHealth Care0.91% - 43
Immunocore Holdings Plc American Depositary Shares, Each Representing One Ordinary Share, Nominal Value ‚0.002 Per Share
IMCR:LNHealth Care0.89% - 44
Xencor Inc
XNCRHealth Care0.88% - 45
Taysha Gene Therapies Inc
TSHAHealth Care0.87% - 46
Bicara Therapeutics, Inc.
BCAXHealth Care0.81% - 47
Maze Therapeutics Inc
MAZEHealth Care0.77% - 48
Tyra Biosciences Inc
TYRAHealth Care0.77% - 49
ARRIVENT BIOPHARMA INC
AVBPHealth Care0.70% - 50
Lb Pharmaceuticals Inc.
LBRXUnknown0.70% - 51
Seaport Therapeutics Inc
SPTXUnknown0.66% - 52
Immatics Nv
4A3:BEHealth Care0.65% - 53
Corvus Pharmaceuticals Inc
CRVSHealth Care0.64% - 54
Meiragtx Holdings Plc Ordinary Shares
MGTX:KYHealth Care0.64% - 55
Vor Biopharma, Inc.
VORUnknown0.63% - 56
Mannkind Corporation Com New
MNKDHealth Care0.61% - 57
Alto Neuroscience, Inc., Series C
ANROHealth Care0.58% - 58
Wave Life Sciences Ltd
WVEHealth Care0.53% - 59
Kura Oncology Inc
KURAHealth Care0.49% - 60
Eliem Therapeutics Inc.
ELYMHealth Care0.48% - 61
Geron Corp
GERNHealth Care0.48% - 62
Olema Pharmaceuticals Inc
OLMAHealth Care0.48% - 63
Design Therapeutics Inc.
DSGNHealth Care0.47% - 64
Solid Biosciences Inc
SLDBHealth Care0.46% - 65
Theravance Biopharma Inc
TBPHHealth Care0.45% - 66
Candel Therapeutics Inc.
CADLHealth Care0.44% - 67
Spyglass Pharma Inc
SGPUnknown0.43% - 68
Aclaris Therapeutics Inc
ACRSHealth Care0.41% - 69
Rigel Pharmaceuticals Inc Common Stock USD.001
RIGLHealth Care0.40% - 70
Oculis Holding Ag
OCS:SMUnknown0.38% - 71
Allogene Therapeutics
NPCUFUnknown0.36% - 72
Tectonic Therapeutic Inc Pipe
TECXHealth Care0.34% - 73
4d Molecular Therapeutics Inc.
FDMTHealth Care0.33% - 74
AgomAb Therapeutics NV Each ADS represents one common share
AGMB:BRUnknown0.33% - 75
Eikon Therapeutics Inc
EIKNUnknown0.31% - 76
Delcath Sys Inc
DCTHHealth Care0.30% - 77
Altimmune Inc
ALTHealth Care0.29% - 78
NEURogene
NGNEUnknown0.29% - 79
Evommune Inc
EVMNUnknown0.27% - 80
Fulgent Genetics Inc
FLGTHealth Care0.27% - 81
ZURA BIO LTD COMMON STOCK
ZURA:KYUnknown0.27% - 82
Relmada Therapeutics Inc Common Stock
RLMDHealth Care0.26% - 83
C4 Therapeutics Inc
CCCCHealth Care0.24% - 84
Contineum Therapeutics, Inc.
CTNMHealth Care0.24% - 85
Rezolute Inc Pipe Deal Rzlt
RZLTHealth Care0.23% - 86
COMPASS THERAPEUTICS INC
CMPXHealth Care0.21% - 87
Enanta Pharmaceuticals Inc
ENTAHealth Care0.20% - 88
Upstream Bio Inc
UPBHealth Care0.20% - 89
X4 Pharmaceuticals Inc
XFORHealth Care0.20% - 90
Immuneering Corp.
IMRXHealth Care0.17% - 91
Inhibikase Thera
IKTHealth Care0.16% - 92
Anavex Life Scienc Com New
AVXLHealth Care0.15% - 93
Sionna Therapeutics Inc
SIONHealth Care0.15% - 94
Macrogenics Inc
MGNXHealth Care0.14% - 95
Sab Biotherapeutics, Inc.
SABSHealth Care0.14% - 96
Fulcrum Therapeutics Inc Com
FULCHealth Care0.13% - 97
I Mab
IMABUnknown0.12% - 98
Arcturus Therapeutics Holdings Inc.
ARCTUnknown0.12% - 99
Akebia Therapeutics Inc
AKBAHealth Care0.12% - 100
Immunic Inc.
IMUXUnknown0.11% - 101
Protara Therapeutics Inc
TARAHealth Care0.11% - 102
Bicycle Therapeutics Plc-Adr
BCYC:LNHealth Care0.10% - 103
Tenax Therapeutics Inc
TENXUnknown0.02% - 104
Astrazeneca Plc
Other0.00% - 105
Chinook Therapeutics Inc.
Other0.00% - 106
Cash Equivalent
Other0.00% - 107
Novo Nordisk A/S Class B[Novo.B]
NOVO.B:COUnknown0.00%
| # | Company | Ticker | Sector | Industry | Weight |
|---|---|---|---|---|---|
| 1 | Crinetics Pharmaceuticals Inc Com | CRNX | 4.550% | ||
| 2 | Apogee Therapeutics Inc | APGE | 4.240% | ||
| 3 | Oruka Therapeutics Inc Orka | ORKA | 3.410% | ||
| 4 | Cg Oncology Inc | CGON | 3.370% | ||
| 5 | Dianthus Therapeutics Inc Common Stock USD.001 | DNTH | 3.230% | ||
| 6 | Xenon Pharmaceuticals Inc. Common Shares | XENE:CA | 3.070% | ||
| 7 | Travere Therapeutics Inc | TVTX | 2.940% | ||
| 8 | Acadia Pharmaceuticals Inc | ACAD | 2.460% | ||
| 9 | Edgewise Therapeutics Inc. | EWTX | 2.420% | ||
| 10 | Veradermics Inc | MANE | 2.390% | ||
| 11 | Definium Therapeutics, Inc. Common Shares | DFTX:CA | 2.370% | ||
| 12 | Relay Therapeutics Inc | RLAY | 2.200% | ||
| 13 | Dynegy | DYN | 2.170% | ||
| 14 | Structure Therapeutics Inc | GPCR | 1.980% | ||
| 15 | Denali Therapeutics Inc | DNLI | 1.970% | ||
| 16 | Celldex Therapeutics Inc | CLDX | 1.680% | ||
| 17 | Mbx Biosciences Inc | MBX | 1.660% | ||
| 18 | Ideaya Biosciences Inc | IDYA | 1.630% | ||
| 19 | Newamsterdam Pharma Company Nv | NAMS | 1.610% | ||
| 20 | Immunome Inc | IMNM | 1.570% | ||
| 21 | Disc Medicine Inc | IRON | 1.530% | ||
| 22 | Tarsus Pharmaceuticals Inc | TARS | 1.510% | ||
| 23 | Zai Lab Ltd | ZLAB | 1.440% | ||
| 24 | BioCryst Pharmaceuticals Inc. | BCRX | 1.260% | ||
| 25 | Nektar Therapeutics | NKTR | 1.260% | ||
| 26 | Viridian Therapeutics Inc | VRDN | 1.240% | ||
| 27 | Amylyx Pharmaceuticals Inc | AMLX | 1.230% | ||
| 28 | Sellas Life Sciences Group Inc. | SLS | 1.210% | ||
| 29 | Kailera Therapeutics Inc | KLRA | 1.190% | ||
| 30 | Vera Therapeutics Inc Ser C Pc Pp | VERA | 1.160% | ||
| 31 | Mineralys Therapeutics Inc | MLYS | 1.150% | ||
| 32 | Rapport Therapeutics, Inc. | RAPP | 1.150% | ||
| 33 | Vericel Corp Ord | VCEL | 1.150% | ||
| 34 | Palvella Therapeutics Inc | PVLA | 1.130% | ||
| 35 | Nuvation Bio Inc. | NUVB | 1.100% | ||
| 36 | Generate Biomedicines Inc | GENB | 1.020% | ||
| 37 | Agios Pharmaceuticals Inc | AGIO | 1.020% | ||
| 38 | Stoke Therapeutics Inc Com | STOK | 0.990% | ||
| 39 | Sarepta Therapeutics Inc | SRPT | 0.970% | ||
| 40 | Zenas Biopharma Inc | ZBIO | 0.950% | ||
| 41 | COMPASS PATHWAYS PLC | CMPS | 0.930% | ||
| 42 | Lakefront Biotherapeutics Sponsored Adr (1 Ads : 1 Ordinary) | GLPG:BR | 0.910% | ||
| 43 | Immunocore Holdings Plc American Depositary Shares, Each Representing One Ordinary Share, Nominal Value ‚0.002 Per Share | IMCR:LN | 0.890% | ||
| 44 | Xencor Inc | XNCR | 0.880% | ||
| 45 | Taysha Gene Therapies Inc | TSHA | 0.870% | ||
| 46 | Bicara Therapeutics, Inc. | BCAX | 0.810% | ||
| 47 | Maze Therapeutics Inc | MAZE | 0.770% | ||
| 48 | Tyra Biosciences Inc | TYRA | 0.770% | ||
| 49 | ARRIVENT BIOPHARMA INC | AVBP | 0.700% | ||
| 50 | Lb Pharmaceuticals Inc. | LBRX | 0.700% | ||
| 51 | Seaport Therapeutics Inc | SPTX | 0.660% | ||
| 52 | Immatics Nv | 4A3:BE | 0.650% | ||
| 53 | Corvus Pharmaceuticals Inc | CRVS | 0.640% | ||
| 54 | Meiragtx Holdings Plc Ordinary Shares | MGTX:KY | 0.640% | ||
| 55 | Vor Biopharma, Inc. | VOR | 0.630% | ||
| 56 | Mannkind Corporation Com New | MNKD | 0.610% | ||
| 57 | Alto Neuroscience, Inc., Series C | ANRO | 0.580% | ||
| 58 | Wave Life Sciences Ltd | WVE | 0.530% | ||
| 59 | Kura Oncology Inc | KURA | 0.490% | ||
| 60 | Eliem Therapeutics Inc. | ELYM | 0.480% | ||
| 61 | Geron Corp | GERN | 0.480% | ||
| 62 | Olema Pharmaceuticals Inc | OLMA | 0.480% | ||
| 63 | Design Therapeutics Inc. | DSGN | 0.470% | ||
| 64 | Solid Biosciences Inc | SLDB | 0.460% | ||
| 65 | Theravance Biopharma Inc | TBPH | 0.450% | ||
| 66 | Candel Therapeutics Inc. | CADL | 0.440% | ||
| 67 | Spyglass Pharma Inc | SGP | 0.430% | ||
| 68 | Aclaris Therapeutics Inc | ACRS | 0.410% | ||
| 69 | Rigel Pharmaceuticals Inc Common Stock USD.001 | RIGL | 0.400% | ||
| 70 | Oculis Holding Ag | OCS:SM | 0.380% | ||
| 71 | Allogene Therapeutics | NPCUF | 0.360% | ||
| 72 | Tectonic Therapeutic Inc Pipe | TECX | 0.340% | ||
| 73 | 4d Molecular Therapeutics Inc. | FDMT | 0.330% | ||
| 74 | AgomAb Therapeutics NV Each ADS represents one common share | AGMB:BR | 0.330% | ||
| 75 | Eikon Therapeutics Inc | EIKN | 0.310% | ||
| 76 | Delcath Sys Inc | DCTH | 0.300% | ||
| 77 | Altimmune Inc | ALT | 0.290% | ||
| 78 | NEURogene | NGNE | 0.290% | ||
| 79 | Evommune Inc | EVMN | 0.270% | ||
| 80 | Fulgent Genetics Inc | FLGT | 0.270% | ||
| 81 | ZURA BIO LTD COMMON STOCK | ZURA:KY | 0.270% | ||
| 82 | Relmada Therapeutics Inc Common Stock | RLMD | 0.260% | ||
| 83 | C4 Therapeutics Inc | CCCC | 0.240% | ||
| 84 | Contineum Therapeutics, Inc. | CTNM | 0.240% | ||
| 85 | Rezolute Inc Pipe Deal Rzlt | RZLT | 0.230% | ||
| 86 | COMPASS THERAPEUTICS INC | CMPX | 0.210% | ||
| 87 | Enanta Pharmaceuticals Inc | ENTA | 0.200% | ||
| 88 | Upstream Bio Inc | UPB | 0.200% | ||
| 89 | X4 Pharmaceuticals Inc | XFOR | 0.200% | ||
| 90 | Immuneering Corp. | IMRX | 0.170% | ||
| 91 | Inhibikase Thera | IKT | 0.160% | ||
| 92 | Anavex Life Scienc Com New | AVXL | 0.150% | ||
| 93 | Sionna Therapeutics Inc | SION | 0.150% | ||
| 94 | Macrogenics Inc | MGNX | 0.140% | ||
| 95 | Sab Biotherapeutics, Inc. | SABS | 0.140% | ||
| 96 | Fulcrum Therapeutics Inc Com | FULC | 0.130% | ||
| 97 | I Mab | IMAB | 0.120% | ||
| 98 | Arcturus Therapeutics Holdings Inc. | ARCT | 0.120% | ||
| 99 | Akebia Therapeutics Inc | AKBA | 0.120% | ||
| 100 | Immunic Inc. | IMUX | 0.110% | ||
| 101 | Protara Therapeutics Inc | TARA | 0.110% | ||
| 102 | Bicycle Therapeutics Plc-Adr | BCYC:LN | 0.100% | ||
| 103 | Tenax Therapeutics Inc | TENX | 0.020% | ||
| 104 | Astrazeneca Plc | - | 0.000% | ||
| 105 | Chinook Therapeutics Inc. | - | 0.000% | ||
| 106 | Cash Equivalent | - | 0.000% | ||
| 107 | Novo Nordisk A/S Class B[Novo.B] | NOVO.B:CO | 0.000% |