SBIO ETF largest holding is CRNX at 4.74% as of Jun 30, 2026
ALPS Medical Breakthroughs ETF
CRNX is SBIO's largest holding at 4.74% of the fund as of Jun 30, 2026. SBIO is ALPS Medical Breakthroughs ETF.
| # | Ticker | Name | Weight | Cumulative | Shares | Mkt value | Share chg | Sector | Industry |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  C | Crinetics Pharmaceuticals IncHealth Care · Pharmaceuticals | 4.74% | 4.7% | 114,536 | $9.59M | +12.6K | Health Care | Pharmaceuticals |
| 2 |  A | Apogee Therapeutics IncHealth Care · Biotechnology | 4.47% | 9.2% | 67,293 | $9.04M | +12.8K | Health Care | Biotechnology |
| Share changes, sector and industry · Pro | |||||||||
| 3 |  X | Xenon Pharmaceuticals Inc. Common Shares | 3.40% | 12.6% | 104,962 | $6.87M | |||
| 4 |  C | Cg Oncology Inc | 3.29% | 15.9% | 95,913 | $6.65M | |||
| 5 |  D | Dianthus Therapeutics Inc | 3.05% | 19.0% | 59,393 | $6.17M | |||
| 6 |  O | Oruka Therapeutics Inc Orka | 2.99% | 21.9% | 65,567 | $6.04M | |||
| 7 |  T | Travere Therapeutics Inc | 2.87% | 24.8% | 101,048 | $5.80M | |||
| 8 | — | Definium Therapeutics, Inc. Common Shares | 2.53% | 27.3% | 118,594 | $5.12M | |||
| 9 |  M | Veradermics Inc | 2.45% | 29.8% | 45,328 | $4.96M | |||
| 10 |  E | Edgewise Therapeutics Inc. | 2.36% | 32.2% | 117,087 | $4.78M | |||
| 11 |  A | Acadia Pharmaceuticals Inc | 2.28% | 34.4% | 185,989 | $4.62M | |||
| 12 |  D | Dyne Therapeutics Inc | 2.17% | 36.6% | 179,826 | $4.39M | |||
| 13 |  R | Relay Therapeutics Inc | 2.16% | 38.8% | 237,183 | $4.37M | |||
| 14 |  D | Denali Therapeutics Inc | 1.97% | 40.7% | 172,609 | $3.99M | |||
| 15 | — | Structure Therapeutics Inc Adr | 1.88% | 42.6% | 77,314 | $3.80M | |||
| 16 |  N | Newamsterdam Pharma Company Nv | 1.86% | 44.5% | 127,154 | $3.77M | |||
| 17 |  I | Ideaya Biosciences Inc | 1.67% | 46.1% | 95,540 | $3.38M | |||
| 18 |  M | Mbx Biosciences Inc | 1.58% | 47.7% | 51,684 | $3.20M | |||
| 19 |  I | Disc Medicine Inc | 1.52% | 49.2% | 41,508 | $3.08M | |||
| 20 |  C | Celldex Therapeutics Inc | 1.49% | 50.7% | 85,213 | $3.01M | |||
| 21 |  V | Vera Therapeutics Inc Ser C Pc Pp | 1.37% | 52.1% | 78,092 | $2.77M | |||
| 22 |  T | Tarsus Pharmaceuticals Inc | 1.35% | 53.5% | 46,680 | $2.74M | |||
| 23 |  I | Immunome Inc | 1.35% | 54.8% | 123,170 | $2.74M | |||
| 24 |  N | Nektar Therapeutics | 1.29% | 56.1% | 36,789 | $2.60M | |||
| 25 |  B | BioCryst Pharmaceuticals Inc. | 1.28% | 57.4% | 276,547 | $2.58M | |||
| 26 |  M | Mineralys Therapeutics Inc | 1.26% | 58.6% | 95,771 | $2.56M | |||
| 27 |  V | Vericel Corp | 1.24% | 59.9% | 55,462 | $2.50M | |||
| 28 |  K | Kailera Therapeutics Inc | 1.23% | 61.1% | 140,990 | $2.49M | |||
| 29 |  N | Nuvation Bio Inc | 1.20% | 62.3% | 378,833 | $2.43M | |||
| 30 |  A | Agios Pharmaceuticals Inc | 1.16% | 63.5% | 64,640 | $2.35M | |||
| 31 |  V | Viridian Therapeutics Inc | 1.14% | 64.6% | 120,086 | $2.31M | |||
| 32 |  S | Sellas Life Sciences Group Inc. | 1.13% | 65.7% | 202,444 | $2.29M | |||
| 33 |  Z | Zai Lab Ltd | 1.13% | 66.9% | 118,855 | $2.28M | |||
| 34 |  S | Sionna Therapeutics Inc | 1.11% | 68.0% | 49,008 | $2.24M | |||
| 35 |  A | Amylyx Pharmaceuticals Inc | 1.10% | 69.1% | 121,015 | $2.23M | |||
| 36 |  P | Palvella Therapeutics Inc | 1.06% | 70.1% | 15,463 | $2.13M | |||
| 37 |  R | Rapport Therapeutics, Inc. | 1.04% | 71.2% | 51,933 | $2.11M | |||
| 38 |  Z | Zenas Biopharma Inc | 1.03% | 72.2% | 68,544 | $2.08M | |||
| 39 |  S | Stoke Therapeuti | 0.98% | 73.2% | 67,807 | $1.99M | |||
| 40 |  T | Tyra Biosciences Inc | 0.98% | 74.2% | 64,740 | $1.98M | |||
| 41 |  L | Lakefront Biotherapeutics Sponsored Adr (1 Ads : 1 Ordinary) | 0.97% | 75.1% | 70,545 | $1.96M | |||
| 42 | — | Immunocore Holdings Ltd Adr | 0.96% | 76.1% | 55,344 | $1.94M | |||
| 43 |  B | Bicara Therapeutics, Inc. | 0.95% | 77.0% | 71,249 | $1.93M | |||
| 44 |  G | Generate Biomedicines Inc | 0.92% | 78.0% | 139,288 | $1.87M | |||
| 45 |  S | Sarepta Therapeutics Inc | 0.89% | 78.9% | 114,685 | $1.80M | |||
| 46 |  T | Taysha Gene Therapies Inc | 0.85% | 79.7% | 312,692 | $1.73M | |||
| 47 |  M | Maze Therapeutics Inc | 0.82% | 80.5% | 60,236 | $1.67M | |||
| 48 |  C | Compass Pathways Plc Adr | 0.82% | 81.3% | 146,866 | $1.65M | |||
| 49 |  A | Arrivent Biopharma Inc | 0.79% | 82.1% | 50,665 | $1.61M | |||
| 50 |  X | Xencor Inc | 0.77% | 82.9% | 80,361 | $1.56M | |||
| More holdings · Pro | |||||||||
SBIO ETF All Holdings
SBIO holdings total 107 positions. The top 10 holdings account for 32.2% of the fund, led by Crinetics Pharmaceuticals Inc Com at 4.7%, Apogee Therapeutics Inc at 4.5%, Xenon Pharmaceuticals Inc. Common Shares at 3.4%.
SBIO portfolio concentration is moderate, with the top 10 representing 32.2% of total assets. The largest sector exposure is Health Care at 88.2%.
SBIO sectors provide a detailed breakdown. SBIO overlap shows how holdings compare to other funds in your portfolio.
SBIO ETF Holdings
106 of 107 holdings
- 1
Crinetics Pharmaceuticals Inc Com
CRNXHealth Care4.74% - 2
Apogee Therapeutics Inc
APGEHealth Care4.47% - 3
Xenon Pharmaceuticals Inc. Common Shares
XENEHealth Care3.40% - 4
Cg Oncology Inc
CGONHealth Care3.29% - 5
Dianthus Therapeutics Inc
DNTHHealth Care3.05% - 6
Oruka Therapeutics Inc Orka
ORKAHealth Care2.99% - 7
Travere Therapeutics Inc
TVTXHealth Care2.87% - 8
Definium Therapeutics, Inc. Common Shares
DFTX:CAUnknown2.53% - 9
Veradermics Inc
MANEUnknown2.45% - 10
Edgewise Therapeutics Inc.
EWTXHealth Care2.36% - 11
Acadia Pharmaceuticals Inc
ACADHealth Care2.28% - 12
Dyne Therapeutics Inc
DYNHealth Care2.17% - 13
Relay Therapeutics Inc
RLAYHealth Care2.16% - 14
Denali Therapeutics Inc
DNLIHealth Care1.97% - 15
Structure Therapeutics Inc Adr
GPCR:SHHealth Care1.88% - 16
Newamsterdam Pharma Company Nv
NAMSHealth Care1.86% - 17
Ideaya Biosciences Inc
IDYAHealth Care1.67% - 18
Mbx Biosciences Inc
MBXHealth Care1.58% - 19
Disc Medicine Inc
IRONHealth Care1.52% - 20
Celldex Therapeutics Inc
CLDXHealth Care1.49% - 21
Vera Therapeutics Inc Ser C Pc Pp
VERAHealth Care1.37% - 22
Tarsus Pharmaceuticals Inc
TARSHealth Care1.35% - 23
Immunome Inc
IMNMHealth Care1.35% - 24
Nektar Therapeutics
NKTRHealth Care1.29% - 25
BioCryst Pharmaceuticals Inc.
BCRXHealth Care1.28% - 26
Mineralys Therapeutics Inc
MLYSHealth Care1.26% - 27
Vericel Corp
VCELHealth Care1.24% - 28
Kailera Therapeutics Inc
KLRAUnknown1.23% - 29
Nuvation Bio Inc
NUVBHealth Care1.20% - 30
Agios Pharmaceuticals Inc
AGIOHealth Care1.16% - 31
Viridian Therapeutics Inc
VRDNHealth Care1.14% - 32
Sellas Life Sciences Group Inc.
SLSHealth Care1.13% - 33
Zai Lab Ltd
ZLABHealth Care1.13% - 34
Sionna Therapeutics Inc
SIONHealth Care1.11% - 35
Amylyx Pharmaceuticals Inc
AMLXHealth Care1.10% - 36
Palvella Therapeutics Inc
PVLAHealth Care1.06% - 37
Rapport Therapeutics, Inc.
RAPPHealth Care1.04% - 38
Zenas Biopharma Inc
ZBIOHealth Care1.03% - 39
Stoke Therapeuti
STOKHealth Care0.98% - 40
Tyra Biosciences Inc
TYRAHealth Care0.98% - 41
Lakefront Biotherapeutics Sponsored Adr (1 Ads : 1 Ordinary)
GLPG:BRHealth Care0.97% - 42
Immunocore Holdings Ltd Adr
IMCR:LNHealth Care0.96% - 43
Bicara Therapeutics, Inc.
BCAXHealth Care0.95% - 44
Generate Biomedicines Inc
GENBUnknown0.92% - 45
Sarepta Therapeutics Inc
SRPTHealth Care0.89% - 46
Taysha Gene Therapies Inc
TSHAHealth Care0.85% - 47
Maze Therapeutics Inc
MAZEHealth Care0.82% - 48
Compass Pathways Plc Adr
CMPSHealth Care0.82% - 49
ARRIVENT BIOPHARMA INC
AVBPHealth Care0.79% - 50
Xencor Inc
XNCRHealth Care0.77% - 51
Mannkind Corp.
MNKDHealth Care0.69% - 52
Immatics Nv
4A3:BEHealth Care0.66% - 53
Seaport Therapeutics Inc
SPTXUnknown0.61% - 54
Wave Life Sciences Ltd
WVEHealth Care0.60% - 55
Corvus Pharmaceuticals Inc
CRVSHealth Care0.59% - 56
Meiragtx Holdings Plc Com Usd0.00003881
MGTXHealth Care0.58% - 57
Vor Biopharma, Inc.
VORUnknown0.56% - 58
Olema Pharmaceuticals Inc
OLMAHealth Care0.55% - 59
Lb Pharmaceuticals Inc.
LBRXUnknown0.54% - 60
Alto Neuroscience, Inc., Series C
ANROHealth Care0.51% - 61
Kura Oncology Inc
KURAHealth Care0.50% - 62
Geron Corp
GERNHealth Care0.49% - 63
Theravance Biopharma Inc
TBPHHealth Care0.47% - 64
Solid Biosciences Inc
SLDBHealth Care0.42% - 65
Design Therapeutics Inc.
DSGNHealth Care0.40% - 66
Climb Bio Inc
CLYMHealth Care0.40% - 67
Aclaris Therapeutics Inc
ACRSHealth Care0.39% - 68
Candel Therapeutics Inc.
CADLHealth Care0.38% - 69
Rigel Pharmaceuticals Inc Common Stock USD.001
RIGLHealth Care0.37% - 70
Spyglass Pharma Inc
SGPUnknown0.37% - 71
Oculis Holding Ag
OCS:SMUnknown0.34% - 72
AgomAb Therapeutics NV Each ADS represents one common share
AGMB:BRUnknown0.33% - 73
Tectonic Therapeutic Inc Pipe
TECXHealth Care0.31% - 74
NEURogene
NGNEUnknown0.30% - 75
Fulgent Genetics Inc
FLGTHealth Care0.30% - 76
Altimmune Inc
ALTHealth Care0.29% - 77
Relmada Therapeutics Inc Common Stock
RLMDHealth Care0.29% - 78
4d Molecular Therapeutics Inc.
FDMTHealth Care0.28% - 79
ZURA BIO LTD COMMON STOCK
ZURA:KYUnknown0.27% - 80
Rezolute Inc Pipe Deal Rzlt
RZLTHealth Care0.26% - 81
Eikon Therapeutics Inc
EIKNUnknown0.26% - 82
Contineum Therapeutics, Inc.
CTNMHealth Care0.25% - 83
Delcath Sys Inc
DCTHHealth Care0.23% - 84
Evommune Inc
EVMNUnknown0.22% - 85
Tenax Therapeutics Inc
TENXUnknown0.21% - 86
X4 Pharmaceuticals Inc
XFORHealth Care0.20% - 87
C4 Therapeutics Inc
CCCCHealth Care0.20% - 88
COMPASS THERAPEUTICS INC
CMPXHealth Care0.20% - 89
Enanta Pharmaceuticals Inc
ENTAHealth Care0.20% - 90
Upstream Bio Inc
UPBHealth Care0.19% - 91
Akebia Therapeutics Inc
AKBAHealth Care0.18% - 92
Inhibikase Thera
IKTHealth Care0.17% - 93
Immuneering Corp.
IMRXHealth Care0.15% - 94
Sab Biotherapeutics, Inc.
SABSHealth Care0.14% - 95
Macrogenics Inc
MGNXHealth Care0.13% - 96
Fulcrum Therapeutics Inc Com
FULCHealth Care0.13% - 97
Anavex Life Scienc Com New
AVXLHealth Care0.12% - 98
Protara Therapeutics Inc
TARAHealth Care0.12% - 99
Bicycle Therapeutics Plc-Adr
BCYC:LNHealth Care0.11% - 100
I Mab
IMABUnknown0.11% - 101
Immunic Inc.
IMUXUnknown0.10% - 102
Arcturus Therapeutics Holdings Inc.
ARCTUnknown0.08% - 103
Cash & Cash Equivalents
Other0.03% - 104
AstraZeneca PLC
AZN:LNUnknown0.00% - 105
Novo Nordisk As
NOVO.B:COUnknown0.00% - 106
Contra Chinook Therape
KDNYUnknown0.00%
| # | Company | Ticker | Sector | Industry | Weight |
|---|---|---|---|---|---|
| 1 | Crinetics Pharmaceuticals Inc Com | CRNX | 4.740% | ||
| 2 | Apogee Therapeutics Inc | APGE | 4.470% | ||
| 3 | Xenon Pharmaceuticals Inc. Common Shares | XENE | 3.400% | ||
| 4 | Cg Oncology Inc | CGON | 3.290% | ||
| 5 | Dianthus Therapeutics Inc | DNTH | 3.050% | ||
| 6 | Oruka Therapeutics Inc Orka | ORKA | 2.990% | ||
| 7 | Travere Therapeutics Inc | TVTX | 2.870% | ||
| 8 | Definium Therapeutics, Inc. Common Shares | DFTX:CA | 2.530% | ||
| 9 | Veradermics Inc | MANE | 2.450% | ||
| 10 | Edgewise Therapeutics Inc. | EWTX | 2.360% | ||
| 11 | Acadia Pharmaceuticals Inc | ACAD | 2.280% | ||
| 12 | Dyne Therapeutics Inc | DYN | 2.170% | ||
| 13 | Relay Therapeutics Inc | RLAY | 2.160% | ||
| 14 | Denali Therapeutics Inc | DNLI | 1.970% | ||
| 15 | Structure Therapeutics Inc Adr | GPCR:SH | 1.880% | ||
| 16 | Newamsterdam Pharma Company Nv | NAMS | 1.860% | ||
| 17 | Ideaya Biosciences Inc | IDYA | 1.670% | ||
| 18 | Mbx Biosciences Inc | MBX | 1.580% | ||
| 19 | Disc Medicine Inc | IRON | 1.520% | ||
| 20 | Celldex Therapeutics Inc | CLDX | 1.490% | ||
| 21 | Vera Therapeutics Inc Ser C Pc Pp | VERA | 1.370% | ||
| 22 | Tarsus Pharmaceuticals Inc | TARS | 1.350% | ||
| 23 | Immunome Inc | IMNM | 1.350% | ||
| 24 | Nektar Therapeutics | NKTR | 1.290% | ||
| 25 | BioCryst Pharmaceuticals Inc. | BCRX | 1.280% | ||
| 26 | Mineralys Therapeutics Inc | MLYS | 1.260% | ||
| 27 | Vericel Corp | VCEL | 1.240% | ||
| 28 | Kailera Therapeutics Inc | KLRA | 1.230% | ||
| 29 | Nuvation Bio Inc | NUVB | 1.200% | ||
| 30 | Agios Pharmaceuticals Inc | AGIO | 1.160% | ||
| 31 | Viridian Therapeutics Inc | VRDN | 1.140% | ||
| 32 | Sellas Life Sciences Group Inc. | SLS | 1.130% | ||
| 33 | Zai Lab Ltd | ZLAB | 1.130% | ||
| 34 | Sionna Therapeutics Inc | SION | 1.110% | ||
| 35 | Amylyx Pharmaceuticals Inc | AMLX | 1.100% | ||
| 36 | Palvella Therapeutics Inc | PVLA | 1.060% | ||
| 37 | Rapport Therapeutics, Inc. | RAPP | 1.040% | ||
| 38 | Zenas Biopharma Inc | ZBIO | 1.030% | ||
| 39 | Stoke Therapeuti | STOK | 0.980% | ||
| 40 | Tyra Biosciences Inc | TYRA | 0.980% | ||
| 41 | Lakefront Biotherapeutics Sponsored Adr (1 Ads : 1 Ordinary) | GLPG:BR | 0.970% | ||
| 42 | Immunocore Holdings Ltd Adr | IMCR:LN | 0.960% | ||
| 43 | Bicara Therapeutics, Inc. | BCAX | 0.950% | ||
| 44 | Generate Biomedicines Inc | GENB | 0.920% | ||
| 45 | Sarepta Therapeutics Inc | SRPT | 0.890% | ||
| 46 | Taysha Gene Therapies Inc | TSHA | 0.850% | ||
| 47 | Maze Therapeutics Inc | MAZE | 0.820% | ||
| 48 | Compass Pathways Plc Adr | CMPS | 0.820% | ||
| 49 | ARRIVENT BIOPHARMA INC | AVBP | 0.790% | ||
| 50 | Xencor Inc | XNCR | 0.770% | ||
| 51 | Mannkind Corp. | MNKD | 0.690% | ||
| 52 | Immatics Nv | 4A3:BE | 0.660% | ||
| 53 | Seaport Therapeutics Inc | SPTX | 0.610% | ||
| 54 | Wave Life Sciences Ltd | WVE | 0.600% | ||
| 55 | Corvus Pharmaceuticals Inc | CRVS | 0.590% | ||
| 56 | Meiragtx Holdings Plc Com Usd0.00003881 | MGTX | 0.580% | ||
| 57 | Vor Biopharma, Inc. | VOR | 0.560% | ||
| 58 | Olema Pharmaceuticals Inc | OLMA | 0.550% | ||
| 59 | Lb Pharmaceuticals Inc. | LBRX | 0.540% | ||
| 60 | Alto Neuroscience, Inc., Series C | ANRO | 0.510% | ||
| 61 | Kura Oncology Inc | KURA | 0.500% | ||
| 62 | Geron Corp | GERN | 0.490% | ||
| 63 | Theravance Biopharma Inc | TBPH | 0.470% | ||
| 64 | Solid Biosciences Inc | SLDB | 0.420% | ||
| 65 | Design Therapeutics Inc. | DSGN | 0.400% | ||
| 66 | Climb Bio Inc | CLYM | 0.400% | ||
| 67 | Aclaris Therapeutics Inc | ACRS | 0.390% | ||
| 68 | Candel Therapeutics Inc. | CADL | 0.380% | ||
| 69 | Rigel Pharmaceuticals Inc Common Stock USD.001 | RIGL | 0.370% | ||
| 70 | Spyglass Pharma Inc | SGP | 0.370% | ||
| 71 | Oculis Holding Ag | OCS:SM | 0.340% | ||
| 72 | AgomAb Therapeutics NV Each ADS represents one common share | AGMB:BR | 0.330% | ||
| 73 | Tectonic Therapeutic Inc Pipe | TECX | 0.310% | ||
| 74 | NEURogene | NGNE | 0.300% | ||
| 75 | Fulgent Genetics Inc | FLGT | 0.300% | ||
| 76 | Altimmune Inc | ALT | 0.290% | ||
| 77 | Relmada Therapeutics Inc Common Stock | RLMD | 0.290% | ||
| 78 | 4d Molecular Therapeutics Inc. | FDMT | 0.280% | ||
| 79 | ZURA BIO LTD COMMON STOCK | ZURA:KY | 0.270% | ||
| 80 | Rezolute Inc Pipe Deal Rzlt | RZLT | 0.260% | ||
| 81 | Eikon Therapeutics Inc | EIKN | 0.260% | ||
| 82 | Contineum Therapeutics, Inc. | CTNM | 0.250% | ||
| 83 | Delcath Sys Inc | DCTH | 0.230% | ||
| 84 | Evommune Inc | EVMN | 0.220% | ||
| 85 | Tenax Therapeutics Inc | TENX | 0.210% | ||
| 86 | X4 Pharmaceuticals Inc | XFOR | 0.200% | ||
| 87 | C4 Therapeutics Inc | CCCC | 0.200% | ||
| 88 | COMPASS THERAPEUTICS INC | CMPX | 0.200% | ||
| 89 | Enanta Pharmaceuticals Inc | ENTA | 0.200% | ||
| 90 | Upstream Bio Inc | UPB | 0.190% | ||
| 91 | Akebia Therapeutics Inc | AKBA | 0.180% | ||
| 92 | Inhibikase Thera | IKT | 0.170% | ||
| 93 | Immuneering Corp. | IMRX | 0.150% | ||
| 94 | Sab Biotherapeutics, Inc. | SABS | 0.140% | ||
| 95 | Macrogenics Inc | MGNX | 0.130% | ||
| 96 | Fulcrum Therapeutics Inc Com | FULC | 0.130% | ||
| 97 | Anavex Life Scienc Com New | AVXL | 0.120% | ||
| 98 | Protara Therapeutics Inc | TARA | 0.120% | ||
| 99 | Bicycle Therapeutics Plc-Adr | BCYC:LN | 0.110% | ||
| 100 | I Mab | IMAB | 0.110% | ||
| 101 | Immunic Inc. | IMUX | 0.100% | ||
| 102 | Arcturus Therapeutics Holdings Inc. | ARCT | 0.080% | ||
| 103 | Cash & Cash Equivalents | - | 0.030% | ||
| 104 | AstraZeneca PLC | AZN:LN | 0.000% | ||
| 105 | Novo Nordisk As | NOVO.B:CO | 0.000% | ||
| 106 | Contra Chinook Therape | KDNY | 0.000% |