MEDX vs VOO

MEDX vs VOO
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Quick Verdict

VOO has a lower expense ratio. MEDX delivered stronger 1-year returns. VOO offers more diversification with 509 holdings.

Lower Fees: VOOHigher Returns: MEDXMore Diversified: VOO

Side-by-Side Comparison

MetricMEDXVOOWinner
Expense Ratio0.85%0.03%
AUM$17M$997.4B
Dividend Yield1.17%1.08%
Holdings34509
YTD Return+11.52%+12.25%
1Y Return+30.95%+20.92%
3Y Return (annualized)+10.47%+21.79%
5Y Return (annualized)-+13.05%
Volatility (annualized)14.5%14.1%
Max Drawdown-21.6%-34.3%
Fund FamilyHorizon Kinetics LLCVanguard (US)
CategoryEquityEquity
InceptionJan 27, 2023Sep 7, 2010

MEDX vs VOO Performance

Horizon Kinetics Medical ETF (MEDX) is a ETF from Horizon Kinetics LLC and Vanguard S&P 500 ETF (VOO) is a ETF from Vanguard (US). Over the past year MEDX returned +30.95% while VOO returned +20.92%. Year to date, MEDX is up 11.52% versus a gain of 12.25% for VOO.

Over three years, MEDX compounded at +10.47% per year against +21.79% for VOO. Across the full 4-year window we track, VOO has the edge at +13.45% annualized vs +8.07%. Past performance does not guarantee future results.

Risk: Volatility and Drawdowns

MEDX has been the more volatile fund, with annualized monthly volatility of 14.5% compared with 14.1% for VOO. Lower volatility generally means a smoother ride, though it often comes with lower long-run returns.

The deepest peak-to-trough decline in our data was -21.6% for MEDX and -34.3% for VOO. Drawdown depth is worth weighing if you expect to sell during market stress rather than ride it out.

The two funds' monthly returns correlate at 0.39. They move independently enough that combining them can meaningfully diversify a portfolio.

Fees and Cost Over Time

MEDX charges 0.85% per year while VOO charges 0.03%. On a $10,000 position that is $85 vs $3 annually, a gap of $82 per year that compounds over a long holding period. On income, MEDX currently yields 1.17% against 1.08% for VOO.

Holdings Overlap

4.5%overlap

MEDX and VOO share 11 holdings out of 525 unique holdings combined, representing a 4.5% weight overlap.

Moderate overlap means holding both could provide meaningful diversification benefits.

Top Shared Holdings

StockWeight in MEDXWeight in VOODifference
LLY19.16%1.47%17.69%
ABBV9.45%0.69%8.76%
JNJ5.99%0.95%5.04%
BMYProProPro
AMGNProProPro
MRKProProPro
PFEProProPro
BIIBProProPro
REGNProProPro
GEHCProProPro
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Frequently Asked Questions

Which is cheaper, MEDX or VOO?

MEDX has an expense ratio of 0.85% while VOO charges 0.03%. VOO is the cheaper option. On a $10,000 investment, that is $82 per year of difference.

Which performed better, MEDX or VOO?

Over the past year MEDX returned +30.95% vs +20.92% for VOO, so MEDX leads on 1-year performance. Over the longest common window we track (4 years), MEDX annualized +8.07% vs +13.45% for VOO. Past performance does not guarantee future results.

Which is riskier, MEDX or VOO?

MEDX has been the more volatile fund at 14.5% annualized versus 14.1% for VOO. Worst drawdown: MEDX -21.6% vs VOO -34.3%.

Should I hold both MEDX and VOO?

MEDX and VOO have a monthly-return correlation of 0.39, so combining them can provide real diversification depending on your allocation goals.

What is the holdings overlap between MEDX and VOO?

MEDX and VOO share 11 common holdings with a 4.5% weight overlap. Combined, they hold 525 unique securities.

Which pays a higher dividend, MEDX or VOO?

MEDX yields 1.17% while VOO yields 1.08%, so MEDX currently pays the higher dividend yield.

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