PBE ETF largest holding is VRTX at 5.19% as of Jun 30, 2026

PBE ETF largest holding is VRTX at 5.19% as of Jun 30, 2026
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VRTX is PBE's largest holding at 5.19% of the fund as of Jun 30, 2026. PBE is Invesco Biotechnology and Genome ETF.

Showing top 33 of 33 holdings · as of Jun 30, 2026
PBE holdings, by weight
#TickerNameWeightCumulativeSharesMkt valueSectorIndustry
1
VRTX
Vertex Pharmaceuticals IncHealth Care · Pharmaceuticals
5.19%		5.2%28,896$14.44MHealth CarePharmaceuticals
2
BIIB
Biogen Inc.Health Care · Biotechnology
5.08%		10.3%65,241$14.13MHealth CareBiotechnology
Sector and industry · Pro
3
AMGN
Amgen Inc.
4.86%		15.1%37,497$13.52M
4—Rpi International Holdings Lp P/P
4.80%		19.9%233,880$13.35M
5
REGN
Regeneron Pharmaceuticals, Inc.
4.51%		24.4%19,849$12.54M
6
ALNY
Alnylam Pharmac..
4.50%		28.9%42,629$12.51M
7
GILD
Gilead Sciences Inc
4.28%		33.2%94,196$11.90M
8
UTHR
United Therapeutics Corp
4.27%		37.5%21,777$11.87M
9
TECH
Bio-Techne Cor
3.65%		41.1%143,235$10.16M
10
CDNA
Caredx Inc
3.36%		44.5%318,987$9.34M
11
VCYT
Veracyte Inc (vcyt)
3.36%		47.9%155,417$9.35M
12
VCEL
Vericel
3.18%		51.0%196,482$8.86M
13
ILMN
Illumina Inc.
3.08%		54.1%47,313$8.57M
14
PTGX
Protagonist Therapeutics Inc
3.01%		57.1%68,723$8.36M
15
PTCT
Ptc Therapeutics Inc
2.98%		60.1%101,567$8.28M
16
RGEN
Repligen Inc.
2.94%		63.0%59,649$8.17M
17
ACAD
ACADia Pharmaceuticals Inc
2.93%		66.0%323,188$8.14M
18
INCY
Incyte
2.92%		68.9%70,762$8.11M
19
ANAB
Anaptysbio Inc
2.82%		71.7%118,937$7.85M
20
BCRX
Biocryst Pharmaceuticals
2.79%		74.5%811,213$7.75M
21—Qiagen Nv
2.77%		77.3%193,331$7.69M
22
HALO
Halozyme Therapeutics Inc
2.77%		80.0%99,985$7.72M
23
NBIX
Neurocrine Biosciences Inc
2.70%		82.7%44,121$7.50M
24
BMRN
Biomarin Pharmaceutical Inc.
2.69%		85.4%129,935$7.49M
25
EXEL
Exelixis Inc
2.68%		88.1%137,474$7.46M
26
COLL
Collegium Pharmaceutical Inc
2.63%		90.7%203,404$7.32M
27
SRPT
Sarepta Therapeutics Inc
2.52%		93.3%412,176$7.02M
28—Legend Biotech Corp-Adr Sedol Bmx9K07
2.46%		95.7%232,678$6.84M
29—Omers Realty Corp
2.10%		97.8%589,783$5.84M
30
ARDX
Ardelyx Inc
2.07%		99.9%1,099,356$5.75M
31
AGPXX
Invesco Government & Agency Portfolio, Institutional Class
0.09%		100.0%260,235$260.2K
32—Salt River Project Agricultural Improvement & Power District 5 2028-01-01
0.00%		100.0%1-
33—Servicetitan Inc Class A option
0.00%		100.0%5,728$5.7K
Not reported for this fund: share changes.
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PBE ETF All Holdings

PBE holdings total 33 positions. The top 10 holdings account for 44.5% of the fund, led by Vertex Pharmaceuticals Inc at 5.2%, Biogen Inc. at 5.1%, Amgen Inc. Com at 4.9%.

PBE portfolio concentration is moderate, with the top 10 representing 44.5% of total assets. The largest sector exposure is Health Care at 87.4%.

PBE sector allocation provides a detailed breakdown. PBE overlap tool shows how holdings compare to other funds in your portfolio.

Compare PBE

PBE vs SPYPBE vs QQQPBE vs VOOPBE vs VTIPBE vs IVVPBE vs SCHDPBE vs VYMPBE vs VXUS

PBE ETF Holdings

33 of 33 holdings

  • 1

    Vertex Pharmaceuticals Inc

    VRTXHealth Care
    5.19%
  • 2

    Biogen Inc.

    BIIBHealth Care
    5.08%
  • 3

    Amgen Inc. Com

    AMGNHealth Care
    4.86%
  • 4

    Rpi International Holdings Lp P/P

    RPD:DUFinancials
    4.80%
  • 5

    Regeneron Pharmaceuticals, Inc.

    REGNHealth Care
    4.51%
  • 6

    Alnylam Pharmac..

    ALNYHealth Care
    4.50%
  • 7

    Gilead Sciences Inc

    GILDHealth Care
    4.28%
  • 8

    United Therapeutics Corp|385

    UTHRHealth Care
    4.27%
  • 9

    Bio-Techne Cor

    TECHHealth Care
    3.65%
  • 10

    Caredx Inc

    CDNAHealth Care
    3.36%
  • 11

    Veracyte Inc (vcyt)

    VCYTHealth Care
    3.36%
  • 12

    Vericel

    VCELHealth Care
    3.18%
  • 13

    Illumina Inc.

    ILMNHealth Care
    3.08%
  • 14

    Protagonist Therapeutics Inc

    PTGXHealth Care
    3.01%
  • 15

    Ptc Therapeutics Inc

    PTCTHealth Care
    2.98%
  • 16

    Repligen Inc.

    RGENHealth Care
    2.94%
  • 17

    ACADia Pharmaceuticals Inc Com USD0.0001

    ACADHealth Care
    2.93%
  • 18

    Incyte

    INCYHealth Care
    2.92%
  • 19

    Anaptysbio Inc

    ANABUnknown
    2.82%
  • 20

    Biocryst Pharmaceuticals

    BCRXHealth Care
    2.79%
  • 21

    Qiagen Nv

    QGEN:ASUnknown
    2.77%
  • 22

    Halozyme Therapeutics Inc

    HALOHealth Care
    2.77%
  • 23

    Neurocrine Biosciences Inc

    NBIXHealth Care
    2.70%
  • 24

    Biomarin Pharmaceutical Inc.

    BMRNHealth Care
    2.69%
  • 25

    Exelixis Inc

    EXELHealth Care
    2.68%
  • 26

    Collegium Pharmaceutical Inc

    COLLHealth Care
    2.63%
  • 27

    Sarepta Therapeutics Inc

    SRPTHealth Care
    2.52%
  • 28

    Legend Biotech Corp-Adr Sedol Bmx9K07

    LEGNHealth Care
    2.46%
  • 29

    Omers Realty Corp

    OMERHealth Care
    2.10%
  • 30

    Ardelyx Inc

    ARDXUnknown
    2.07%
  • 31

    Invesco Government & Agency Portfolio, Institutional Class

    AGPXXFinancials
    0.09%
  • 32

    Salt River Project Agricultural Improvement & Power District 5 2028-01-01

    Other
    0.00%
  • 33

    Servicetitan Inc Class A option

    Other
    0.00%