XBI ETF largest holding is MRNA at 1.62% as of Jun 30, 2026

XBI ETF largest holding is MRNA at 1.62% as of Jun 30, 2026
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MRNA is XBI's largest holding at 1.62% of the fund as of Jun 30, 2026. XBI is State Street SPDR S&P Biotech ETF.

Showing top 50 of 160 holdings · as of Jun 30, 2026
XBI holdings, by weight
#TickerNameWeightCumulativeSharesSectorIndustry
1Moderna therapeuticsHealth Care · Biotechnology
1.62%
1.6%2,156,891Health CareBiotechnology
2
APGE
Apogee Therapeutics IncHealth Care · Biotechnology
1.47%
3.1%1,199,234Health CareBiotechnology
Share changes, sector and industry · Pro
3
TWST
Twist Bioscience Corp.
1.35%
4.4%1,463,691
4
KYMR
Kymera Therapeutics Inc
1.34%
5.8%1,268,064
5
ERAS
Erasca Inc.
1.29%
7.1%7,419,695
6
VKTX
Viking Therapeutics Inc
1.27%
8.3%3,574,768
7
NTRA
Natera Inc
1.20%
9.5%458,237
8
RVMD
Revolution Medicines Inc
1.20%
10.7%687,949
9
ORKA
Oruka Therapeutics Inc Orka
1.19%
11.9%1,549,262
10
PRAX
Praxis Precision Medicines, Inc.
1.19%
13.1%412,207
11
RYTM
Rhythm Pharmaceuticals Inc
1.19%
14.3%1,157,392
12
MIRM
Mirum Pharmaceuticals Inc
1.18%
15.5%1,055,296
13
CYTK
Cytokinetics Inc
1.17%
16.7%1,478,986
14
CGON
Cg Oncology Inc
1.15%
17.8%1,806,242
15
COGT
Cogent Biosciences Inc
1.15%
19.0%3,161,289
16
SRRK
Scholar Rock Holding Corp
1.15%
20.1%2,249,906
17
PCVX
Vaxcyte Inc
1.15%
21.3%2,184,031
18Alkermes Plc. Ordinary Shares
1.15%
22.4%2,262,805
19
PTGX
Protagonist Therapeutics Inc
1.14%
23.5%937,897
20Roivant Sciences Ltd. Common Shares
1.14%
24.7%3,491,718
21Crispr Therapeutics Ag Common Shares
1.14%
25.8%2,006,430
22
RARE
Ultragenyx Pharmaceutical Inc
1.13%
27.0%3,653,348
23
ARWR
Arrowhead Pharmaceuticals Inc
1.12%
28.1%1,402,397
24
CELC
Celcuity Inc
1.12%
29.2%1,124,179
25
DNTH
Dianthus Therapeutics Inc
1.12%
30.3%1,298,103
26
TVTX
Travere Therapeutics Inc
1.12%
31.4%2,122,275
27
INSM
Insmed Inc
1.11%
32.5%1,079,724
28
SLS
Sellas Life Sciences Group Inc.
1.11%
33.7%8,622,810
29Nvaesrtex Pharmaceuticals Inc
1.11%
34.8%227,635
30
KRYS
Krystal Biotech Inc
1.10%
35.9%317,561
31
BEAM
Beam Therapeutics Inc
1.09%
37.0%3,363,830
32
RLAY
Relay Therapeutics Inc
1.09%
38.1%6,281,451
33
SMMT
Summit Therapeutics Inccommon Stock
1.09%
39.1%7,425,647
34
TGTX
Tg Therapeutics Inc
1.09%
40.2%2,127,835
35
SYRE
Spyre Therapeutics Inc
1.08%
41.3%1,321,145
36
PTCT
Ptc Therapeutics Inc
1.06%
42.4%1,352,456
37
BBIO
Bridgebio Pharma Inc
1.05%
43.4%1,471,731
38
HALO
Halozyme Therapeutics Inc
1.05%
44.5%1,407,148
39
IONS
Ionis Pharmaceuticals Inc
1.04%
45.5%1,353,002
40
ABBV
AbbVie Inc.
1.03%
46.5%440,973
41
MDGL
Madrigal Pharmaceuticals Inc
1.03%
47.6%210,471
42
IBRX
Immunitybio Inc
1.02%
48.6%12,449,949
43
INCY
Incyte Corp.
1.00%
49.6%941,442
44
AMGN
Amgen Inc.
0.99%
50.6%293,773
45
NBIX
Neurocrine Biosciences Inc
0.99%
51.6%616,686
46
REGN
Regeneron Pharmaceuticals, Inc.
0.99%
52.6%164,860
47
ALNY
Alnylam Pharmaceuticals Inc.
0.98%
53.5%340,627
48
BIIB
Biogen Inc.
0.98%
54.5%510,666
49
VERA
Vera Therapeutics Inc Ser C Pc Pp
0.98%
55.5%2,640,417
50
GILD
Gilead Sciences
0.97%
56.5%816,553
More holdings · Pro
Not reported for this fund: market value.
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XBI ETF All Holdings

XBI holdings total 157 positions. The top 10 holdings account for 13.1% of the fund, led by Moderna therapeutics at 1.6%, Apogee Therapeutics Inc at 1.5%, Twist Bioscience Corp. at 1.4%.

XBI portfolio concentration is well-diversified, with the top 10 representing 13.1% of total assets. The largest sector exposure is Health Care at 98.0%.

XBI sectors provide a detailed breakdown. XBI overlap shows how holdings compare to other funds in your portfolio.

XBI ETF Holdings

160 of 157 holdings

  • 1

    Moderna therapeutics

    MRNAHealth Care
    1.62%
  • 2

    Apogee Therapeutics Inc

    APGEHealth Care
    1.47%
  • 3

    Twist Bioscience Corp.

    TWSTHealth Care
    1.35%
  • 4

    Kymera Therapeutics Inc

    KYMRHealth Care
    1.34%
  • 5

    Erasca Inc.

    ERASHealth Care
    1.29%
  • 6

    Viking Therapeutics Inc Com

    VKTXHealth Care
    1.27%
  • 7

    Natera Inc

    NTRAHealth Care
    1.20%
  • 8

    Revolution Medicines Inc

    RVMDHealth Care
    1.20%
  • 9

    Oruka Therapeutics Inc Orka

    ORKAHealth Care
    1.19%
  • 10

    Praxis Precision Medicines, Inc.

    PRAXHealth Care
    1.19%
  • 11

    Rhythm Pharmaceuticals Inc

    RYTMHealth Care
    1.19%
  • 12

    Mirum Pharmaceuticals Inc

    MIRMHealth Care
    1.18%
  • 13

    Cytokinetics Inc

    CYTKHealth Care
    1.17%
  • 14

    Cg Oncology Inc

    CGONHealth Care
    1.15%
  • 15

    Cogent Biosciences Inc

    COGTHealth Care
    1.15%
  • 16

    Scholar Rock Holding Corp

    SRRKHealth Care
    1.15%
  • 17

    Vaxcyte Inc

    PCVXHealth Care
    1.15%
  • 18

    Alkermes Plc. Ordinary Shares

    ALKS:IEHealth Care
    1.15%
  • 19

    Protagonist Therapeutics Inc

    PTGXHealth Care
    1.14%
  • 20

    Roivant Sciences Ltd. Common Shares

    ROIV:BMHealth Care
    1.14%
  • 21

    Crispr Therapeutics Ag Common Shares

    CRSP:SMHealth Care
    1.14%
  • 22

    Ultragenyx Pharmaceutical Inc

    RAREHealth Care
    1.13%
  • 23

    Arrowhead Pharmaceuticals Inc

    ARWRHealth Care
    1.12%
  • 24

    Celcuity Inc Com

    CELCHealth Care
    1.12%
  • 25

    Dianthus Therapeutics Inc

    DNTHHealth Care
    1.12%
  • 26

    Travere Therapeutics Inc

    TVTXHealth Care
    1.12%
  • 27

    Insmed Inc

    INSMHealth Care
    1.11%
  • 28

    Sellas Life Sciences Group Inc.

    SLSHealth Care
    1.11%
  • 29

    Nvaesrtex Pharmaceuticals Inc

    VRTXHealth Care
    1.11%
  • 30

    Krystal Biotech Inc

    KRYSHealth Care
    1.10%
  • 31

    Beam Therapeutics Inc

    BEAMHealth Care
    1.09%
  • 32

    Relay Therapeutics Inc

    RLAYHealth Care
    1.09%
  • 33

    Summit Therapeutics Inccommon Stock

    SMMTHealth Care
    1.09%
  • 34

    Tg Therapeutics Inc Common Stock

    TGTXHealth Care
    1.09%
  • 35

    Spyre Therapeutics Inc

    SYREHealth Care
    1.08%
  • 36

    Ptc Therapeutics Inc

    PTCTHealth Care
    1.06%
  • 37

    Bridgebio Pharma Inc

    BBIOHealth Care
    1.05%
  • 38

    Halozyme Therapeutics Inc

    HALOHealth Care
    1.05%
  • 39

    Ionis Pharmaceuticals Inc

    IONSHealth Care
    1.04%
  • 40

    Abbvie Inc.

    ABBVHealth Care
    1.03%
  • 41

    Madrigal Pharmaceuticals Inc

    MDGLHealth Care
    1.03%
  • 42

    Immunitybio Inc

    IBRXHealth Care
    1.02%
  • 43

    Incyte Corp.

    INCYHealth Care
    1.00%
  • 44

    Amgen Inc.

    AMGNHealth Care
    0.99%
  • 45

    Neurocrine Biosciences Inc

    NBIXHealth Care
    0.99%
  • 46

    Regeneron Pharmaceuticals, Inc.

    REGNHealth Care
    0.99%
  • 47

    Alnylam Pharmaceuticals Inc.

    ALNYHealth Care
    0.98%
  • 48

    Biogen Inc. Com

    BIIBHealth Care
    0.98%
  • 49

    Vera Therapeutics Inc Ser C Pc Pp

    VERAHealth Care
    0.98%
  • 50

    Gilead Sciences

    GILDHealth Care
    0.97%
  • 51

    Biomarin Pharmaceutical Inc.

    BMRNHealth Care
    0.96%
  • 52

    Exelixis Inc

    EXELHealth Care
    0.96%
  • 53

    Acadia Pharmaceuticals Inc

    ACADHealth Care
    0.94%
  • 54

    Intellia Therapeutics Inc

    NTLAHealth Care
    0.94%
  • 55

    Nuvalent

    NUVLHealth Care
    0.92%
  • 56

    United Therapeutics Corp

    UTHRHealth Care
    0.92%
  • 57

    Immunovant Inc

    IMVTHealth Care
    0.91%
  • 58

    Uniqure N.V. Ordinary Shares

    QURE:ASHealth Care
    0.91%
  • 59

    Grail Inc Common Stock Usd

    GRALHealth Care
    0.90%
  • 60

    BioCryst Pharmaceuticals Inc.

    BCRXHealth Care
    0.89%
  • 61

    Dyne Therapeutics Inc

    DYNHealth Care
    0.87%
  • 62

    Catalyst Partners Acquisition Corp Ieu

    CPARUHealth Care
    0.86%
  • 63

    Ideaya Biosciences Inc

    IDYAHealth Care
    0.84%
  • 64

    Denali Therapeutics Inc

    DNLIHealth Care
    0.82%
  • 65

    RECURSION PHARMACEUTICALS-A

    RXRXHealth Care
    0.80%
  • 66

    Veracyte Inc

    VCYTHealth Care
    0.80%
  • 67

    Tango Therapeutics Inc.

    TNGXHealth Care
    0.79%
  • 68

    Sarepta Therapeutics Inc

    SRPTHealth Care
    0.78%
  • 69

    Mineralys Therapeutics Inc

    MLYSHealth Care
    0.75%
  • 70

    Arcus Biosciences Inc

    RCUSHealth Care
    0.71%
  • 71

    Celldex Therapeutics Inc

    CLDXHealth Care
    0.71%
  • 72

    Syndax Pharmaceuticals Inc

    SNDXHealth Care
    0.71%
  • 73

    Arcutis Biotherapeutics Inc

    ARQTHealth Care
    0.70%
  • 74

    Agios Pharmaceuticals Inc

    AGIOHealth Care
    0.69%
  • 75

    Disc Medicine Inc

    IRONHealth Care
    0.68%
  • 76

    Viridian Therapeutics Inc

    VRDNHealth Care
    0.68%
  • 77

    Immunome Inc

    IMNMHealth Care
    0.66%
  • 78

    Adma Biologics Inc Com

    ADMAHealth Care
    0.65%
  • 79

    Novavax Inc

    NVAXHealth Care
    0.65%
  • 80

    Iovance Biotherapeutics Inc

    IOVAHealth Care
    0.56%
  • 81

    Biohaven Ltd

    BHVNUnknown
    0.56%
  • 82

    Absci Corp

    ABSIHealth Care
    0.55%
  • 83

    Nurix Therapeutics Inc

    NRIXHealth Care
    0.54%
  • 84

    Palvella Therapeutics Inc

    PVLAHealth Care
    0.53%
  • 85

    Hyperliquid Strategies Inc

    PURRUnknown
    0.51%
  • 86

    Kodiak Sciences Inc

    KODHealth Care
    0.51%
  • 87

    Vericel Corp

    VCELHealth Care
    0.51%
  • 88

    Stoke Therapeuti

    STOKHealth Care
    0.47%
  • 89

    Anaptysbio Inc

    ANABHealth Care
    0.45%
  • 90

    Capricor Therapeutics Inc

    CAPRHealth Care
    0.45%
  • 91

    Monte Rosa Therapeutics Inc

    GLUEHealth Care
    0.45%
  • 92

    Vir Biotechnology Inc

    VIRHealth Care
    0.45%
  • 93

    Corvus Pharmaceuticals Inc

    CRVSHealth Care
    0.41%
  • 94

    Cullinan Therapeutics Inc

    CGEMHealth Care
    0.39%
  • 95

    Tyra Biosciences Inc

    TYRAHealth Care
    0.39%
  • 96

    Avalo Therapeuti

    AVTXHealth Care
    0.37%
  • 97

    Ardelyx Inc

    ARDXHealth Care
    0.36%
  • 98

    Inhibrx Biosciences Inc

    INBXHealth Care
    0.36%
  • 99

    Precigen Corp

    PGENHealth Care
    0.36%
  • 100

    Annexon Inc

    ANNXHealth Care
    0.34%
  • 101

    Mannkind Corp.

    MNKDHealth Care
    0.33%
  • 102

    Oric Pharmaceuticals, Inc. Series C

    ORICHealth Care
    0.33%
  • 103

    Taysha Gene Therapies Inc

    TSHAHealth Care
    0.33%
  • 104

    Zenas Biopharma Inc

    ZBIOHealth Care
    0.33%
  • 105

    Olema Pharmaceuticals Inc

    OLMAHealth Care
    0.32%
  • 106

    Vor Biopharma Inc

    VORHealth Care
    0.32%
  • 107

    Kura Oncology Inc

    KURAHealth Care
    0.31%
  • 108

    Jade Biosciences Inc

    JBIOHealth Care
    0.30%
  • 109

    Caredx Inc

    CDNAHealth Care
    0.30%
  • 110

    Bicara Therapeutics, Inc.

    BCAXHealth Care
    0.29%
  • 111

    Geron Corp

    GERNHealth Care
    0.29%
  • 112

    Replimune Group Inc Com

    REPLHealth Care
    0.29%
  • 113

    ARRIVENT BIOPHARMA INC

    AVBPHealth Care
    0.28%
  • 114

    Cytomx Therapeutics Inc

    CTMXHealth Care
    0.28%
  • 115

    Janux Therapeutics Inc

    JANXHealth Care
    0.27%
  • 116

    Regenxbio Inc

    RGNXHealth Care
    0.27%
  • 117

    Sana Biotechnology Inc Common Stock Usd.0001

    SANAHealth Care
    0.26%
  • 118

    Sionna Therapeutics Inc

    SIONHealth Care
    0.26%
  • 119

    Solid Biosciences Inc

    SLDBHealth Care
    0.26%
  • 120

    Xencor Inc

    XNCRHealth Care
    0.26%
  • 121

    Rigel Pharmaceuticals Inc

    RIGLUnknown
    0.24%
  • 122

    Allogene Therapeutics Inc

    ALLOHealth Care
    0.23%
  • 123

    Altimmune Inc

    ALTHealth Care
    0.23%
  • 124

    Ironwood Pharmaceuticals Inc

    IRWDHealth Care
    0.22%
  • 125

    Damora Therapeutics Inc

    DMRAHealth Care
    0.20%
  • 126

    Immix Biopharma Inc

    IMMXHealth Care
    0.20%
  • 127

    Candel Therapeutics Inc.

    CADLHealth Care
    0.19%
  • 128

    4d Molecular Therapeutics Inc.

    FDMTHealth Care
    0.19%
  • 129

    Ocugen Inc.

    OCGNHealth Care
    0.19%
  • 130

    Prime Medicine Inc Common Stock USD.00001

    PRMEHealth Care
    0.19%
  • 131

    Savara Inc

    SVRAHealth Care
    0.18%
  • 132

    Arbutus Biopharma Corp.

    ABUSHealth Care
    0.17%
  • 133

    First Tracks Biotherapeutics, Inc.

    TRAXUnknown
    0.17%
  • 134

    Myriad Genetics, Inc.

    MYGNHealth Care
    0.17%
  • 135

    ARS Pharmaceuticals Inc

    SPRYHealth Care
    0.17%
  • 136

    Maplight Therapeutics Inc

    MPLTUnknown
    0.16%
  • 137

    Cabaletta Bio Inc

    CABAHealth Care
    0.15%
  • 138

    COMPASS THERAPEUTICS INC

    CMPXHealth Care
    0.14%
  • 139

    Verastem Inc

    VSTMUnknown
    0.14%
  • 140

    Emergent Biosolutions Inc

    EBSHealth Care
    0.13%
  • 141

    Perspective Ther

    CATXHealth Care
    0.13%
  • 142

    Vanda Pharmaceuticals Inc

    VNDAHealth Care
    0.13%
  • 143

    Prothena Corporation Public Limited Company Ordinary Shares

    PRTA:IEHealth Care
    0.13%
  • 144

    Ovid Therapeutics Inc

    OVIDHealth Care
    0.12%
  • 145

    Mimedx Group Inc Com

    MDXGHealth Care
    0.11%
  • 146

    Lexeo Therapeutics Inc - Series B

    LEXOHealth Care
    0.10%
  • 147

    Achieve Life Sciences Inc

    ACHVHealth Care
    0.08%
  • 148

    Sagimet Biosciences Inc

    SGMTHealth Care
    0.07%
  • 149

    Contra Metsera Inc

    Other
    0.07%
  • 150

    BRIDGEBIO ONCOLOGY THERAPEUTICS IN

    BBOTUnknown
    0.06%
  • 151

    State Street Institutional US Government Money Market Fund

    GVMXXFinancials
    0.04%
  • 152

    Ping An Insu Ran Ce Group Co. Of C Hin A Ltd.

    601318:SHHealth Care
    0.01%
  • 153

    Contra Verve Therapeut

    Other
    0.01%
  • 154

    Contra Inhibrx Inc

    Other
    0.01%
  • 155

    Contra Akero Therapeut Common Stock

    Other
    0.01%
  • 156

    Atrium Therapeutics Inc

    RNAUnknown
    0.00%
  • 157

    Omniab Inc 12.5 Earnout

    OABIHealth Care
    0.00%
  • 158

    Omniab Inc 15.00 Earnout

    OABIHealth Care
    0.00%
  • 159

    US Dollar

    Other
    0.00%
  • 160

    Contra Blueprint Medic

    Other
    0.00%